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    Combination motif immune stimulatory oligonucleotides with improved activity
    2.
    发明授权
    Combination motif immune stimulatory oligonucleotides with improved activity 失效
    具有改善活性的组合基序免疫刺激性寡核苷酸

    公开(公告)号：US08198251B2

    公开(公告)日：2012-06-12

    申请号：US12190402

    申请日：2008-08-12

    申请人： Jorg Vollmer ,  Eugen Uhlmann ,  Arthur M. Krieg ,  Douglas C. Hanson ,  Ulrike Samulowitz

    发明人： Jorg Vollmer ,  Eugen Uhlmann ,  Arthur M. Krieg ,  Douglas C. Hanson ,  Ulrike Samulowitz

    IPC分类号： A61K48/00

    CPC分类号： A61K31/7088 ,  A61K39/39 ,  A61K2039/55561 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/31 ,  C12N2310/315

    摘要： Immunostimulatory oligonucleotides, which contain a CpG immunostimulatory motif and a second motif that is capable of forming secondary structure, including duplex and higher order structures in vitro and in vivo, are disclosed. They include nucleic acids, or pharmaceutically acceptable salts thereof, having base sequences that include 5′ TCGTCGTTTTCGGCGCGCGCCGT 3′ (SEQ ID NO: 1), in which each C is unmethylated and 3′ refers to the 3′ end of the nucleic acid. The oligonucleotides activate B cells and NK cells and induce expression of type I interferon and interferon-γ. The oligonucleotides are useful for treating a variety of disorders and conditions, including allergy, asthma, infection, and cancer. In addition to their use as single agents and as combination therapies, the disclosed oligonucleotides are useful as adjuvants in vaccines.

    摘要翻译： 公开了含有CpG免疫刺激基序和能够形成二级结构的第二基序的免疫刺激性寡核苷酸，包括体外和体内的双链体和高级结构。 它们包括具有碱基序列的核酸或其药学上可接受的盐，其包含5'TCGTCGTTTTCGGCGCGCGCCGT 3'（SEQ ID NO：1），其中每个C是未甲基化的，3'是指核酸的3'末端。 寡核苷酸激活B细胞和NK细胞并诱导I型干扰素和干扰素-γ的表达。 寡核苷酸可用于治疗各种疾病和病症，包括过敏，哮喘，感染和癌症。 除了它们作为单一药剂和联合疗法的用途之外，所公开的寡核苷酸可用作疫苗中的佐剂。

    Combination motif immune stimulatory oligonucleotides with improved activity
    3.
    发明授权
    Combination motif immune stimulatory oligonucleotides with improved activity 有权
    具有改善活性的组合基序免疫刺激性寡核苷酸

    公开(公告)号：US08834900B2

    公开(公告)日：2014-09-16

    申请号：US10224523

    申请日：2002-08-19

    申请人： Arthur M. Krieg ,  Jorg Vollmer

    发明人： Arthur M. Krieg ,  Jorg Vollmer

    IPC分类号： A61K45/00 ,  C07H21/02

    CPC分类号： C12N15/117 ,  A61K38/00 ,  A61K2039/55561 ,  C12N2310/315

    摘要： A class of immunostimulatory nucleic acids having at least two functionally and structurally defined domains is provided. This class of combination motif immunostimulatory nucleic acids activates an immune response and is useful for treating a variety of immune related disorders such as cancer, infectious disease, and allergic disorders. The nucleic acids also stimulate activation of natural killer cells and production of type 1 interferon.

    摘要翻译： 提供了一类具有至少两个功能和结构域定义的免疫刺激核酸。 这类组合基序免疫刺激性核酸激活免疫应答，可用于治疗多种免疫相关疾病，如癌症，感染性疾病和过敏性疾病。 核酸还刺激天然杀伤细胞的活化和1型干扰素的产生。

    IMMUNOSTIMULATORY NUCLEIC ACIDS
    4.
    发明申请
    IMMUNOSTIMULATORY NUCLEIC ACIDS 审中-公开
    免疫球蛋白

    公开(公告)号：US20090191188A1

    公开(公告)日：2009-07-30

    申请号：US12393866

    申请日：2009-02-26

    申请人： Arthur M. Krieg ,  Christian Schetter ,  Jorg Vollmer

    发明人： Arthur M. Krieg ,  Christian Schetter ,  Jorg Vollmer

    IPC分类号： A61K31/7088 ,  A61K39/395 ,  A61K39/00

    CPC分类号： A61K31/7105 ,  A61K31/7088 ,  A61K31/7125 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/55561

    摘要： The invention relates to immunostimulatory nucleic acid compositions and methods of using the compositions. The T-rich nucleic acids contain poly T sequences and/or have greater than 25% T nucleotide residues. The TG nucleic acids have TG dinucleotides. The C-rich nucleic acids have at least one poly-C region and/ore greater than 50% c nucleotides. These immunostimulatory nucleic acids function in a similar manner to nucleic acids containing CpG motifs. The invention also encompasses preferred CpG nucleic acids.

    摘要翻译： 本发明涉及免疫刺激性核酸组合物和使用该组合物的方法。 富含T的核酸含有多T序列和/或具有大于25％的T核苷酸残基。 TG核酸具有TG二核苷酸。 富含C的核酸具有至少一个多C区和/或大于50％c核苷酸。 这些免疫刺激性核酸以与含有CpG基序的核酸类似的方式起作用。 本发明还包括优选的CpG核酸。

    COMBINATION MOTIF IMMUNE STIMULATORY OLIGONUCLEOTIDES WITH IMPROVED ACTIVITY
    6.
    发明申请
    COMBINATION MOTIF IMMUNE STIMULATORY OLIGONUCLEOTIDES WITH IMPROVED ACTIVITY 失效
    具有改善活性的组合动物免疫刺激性寡核苷酸

    公开(公告)号：US20090087446A1

    公开(公告)日：2009-04-02

    申请号：US12190402

    申请日：2008-08-12

    申请人： JORG VOLLMER ,  Eugen Uhlmann ,  Arthur M. Krieg ,  Douglas C. Hanson ,  Ulrike Samulowitz

    发明人： JORG VOLLMER ,  Eugen Uhlmann ,  Arthur M. Krieg ,  Douglas C. Hanson ,  Ulrike Samulowitz

    IPC分类号： A61K39/00 ,  C07H21/00 ,  A61K39/02 ,  A61K39/002 ,  A61K39/12 ,  A61K31/7088

    CPC分类号： A61K31/7088 ,  A61K39/39 ,  A61K2039/55561 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/31 ,  C12N2310/315

    摘要： Immunostimulatory oligonucleotides, which contain a CpG immunostimulatory motif and a second motif that is capable of forming secondary structure, including duplex and higher order structures in vitro and in vivo, are disclosed. They include nucleic acids, or pharmaceutically acceptable salts thereof, having base sequences that include 5′ TCGTCGTTTTCGGCGCGCGCCGT 3′ (SEQ ID NO: 1), in which each C is unmethylated and 3′ refers to the 3′ end of the nucleic acid. The oligonucleotides activate B cells and NK cells and induce expression of type I interferon and interferon-γ. The oligonucleotides are useful for treating a variety of disorders and conditions, including allergy, asthma, infection, and cancer. In addition to their use as single agents and as combination therapies, the disclosed oligonucleotides are useful as adjuvants in vaccines.

    摘要翻译： 公开了含有CpG免疫刺激基序和能够形成二级结构的第二基序的免疫刺激性寡核苷酸，包括体外和体内的双链体和高级结构。 它们包括具有碱基序列的核酸或其药学上可接受的盐，其包含5'TCGTCGTTTTCGGCGCGCGCCGT 3'（SEQ ID NO：1），其中每个C是未甲基化的，3'是指核酸的3'末端。 寡核苷酸激活B细胞和NK细胞并诱导I型干扰素和干扰素-γ的表达。 寡核苷酸可用于治疗各种疾病和病症，包括过敏，哮喘，感染和癌症。 除了它们作为单一药剂和联合疗法的用途之外，所公开的寡核苷酸可用作疫苗中的佐剂。