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公开(公告)号：US08227447B2
公开(公告)日：2012-07-24
申请号：US13360894
申请日：2012-01-30
申请人： Marion Jurk , Jorg Vollmer
发明人： Marion Jurk , Jorg Vollmer
CPC分类号： A61K31/7105 , A61K39/39 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/33
摘要： Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7-associated cytokine IFN-α.
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2.发明授权RNA sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles 有权RNA序列基序在定义的核苷酸间键的背景下诱导特异性免疫调节谱公开(公告)号：US08128944B2
公开(公告)日：2012-03-06
申请号：US12670697
申请日：2008-08-08
申请人： Marion Jurk , Jorg Vollmer
发明人： Marion Jurk , Jorg Vollmer
CPC分类号： A61K31/7105 , A61K39/39 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/33
摘要： Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7-associated cytokine IFN-α.
摘要翻译： 根据本发明提供了含有某些顺序依赖性免疫刺激RNA基序的免疫刺激性聚合物和使用这种免疫刺激性聚合物的方法和含有这些聚合物的组合物。 序列依赖性免疫刺激RNA基序和掺入这种基序的聚合物是TLR7和TLR7相关细胞因子IFN-α的有效和选择性诱导物。
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3.发明申请RNA SEQUENCE MOTIFS IN THE CONTEXT OF DEFINED INTERNUCLEOTIDE LINKAGES INDUCING SPECIFIC IMMUNE MODULATORY PROFILES 有权诱导特异性免疫调节剂分析的定义的核苷酸连接物的RNA序列运动公开(公告)号：US20100272785A1
公开(公告)日：2010-10-28
申请号：US12670697
申请日：2008-08-08
申请人： Marion Jurk , Jorg Vollmer
发明人： Marion Jurk , Jorg Vollmer
CPC分类号： A61K31/7105 , A61K39/39 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/33
摘要： Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7-associated cytokine IFN-α.
摘要翻译： 根据本发明提供了含有某些顺序依赖性免疫刺激RNA基序的免疫刺激性聚合物和使用这种免疫刺激性聚合物的方法和含有这些聚合物的组合物。 序列依赖性免疫刺激RNA基序和掺入这种基序的聚合物是TLR7和TLR7相关细胞因子IFN-α的有效和选择性诱导物。
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公开(公告)号：US20080226649A1
公开(公告)日：2008-09-18
申请号：US11725339
申请日：2007-03-19
申请人： Christian Schetter , Jorg Vollmer
发明人： Christian Schetter , Jorg Vollmer
IPC分类号： A61K39/395 , A61K31/711 , A61P37/00 , A61K39/00
CPC分类号： C07H21/00 , A61K31/7115 , A61K39/39 , A61K2039/55561 , C12N15/111 , C12N15/117 , C12N2310/17 , C12N2320/31
摘要： Immunostimulatory compositions described as CpG-like nucleic acids are provided, including nucleic acids having immunostimulatory characteristics of CpG nucleic acid, despite certain substitutions of C, G, or C and G of the CpG dinucleotide. The substitutions can include, among others, exchange of methylated C for C, inosine for G, and ZpY for CpG, where Z is cytosine or dSpacer and Y is inosine, 2-aminopurine, nebularine, or dSpacer. Also provided are methods for inducing an immune response in a subject using the CpG-like nucleic acids. The methods are useful in the treatment of a subject that has or is at risk of developing an infectious disease, allergy, asthma, cancer, anemia, thrombocytopenia, or neutropenia.
摘要翻译： 提供描述为CpG样核酸的免疫刺激组合物，包括具有CpG核酸的免疫刺激特性的核酸，尽管CpG二核苷酸的C，G或C和G的某些取代。 取代可以包括C的甲基化C，G的肌苷和CpG的ZpY，其中Z是胞嘧啶或dSpacer，Y是肌苷，2-氨基嘌呤，星云素或dSpacer。 还提供了使用CpG样核酸在受试者中诱导免疫应答的方法。 该方法在治疗感染性疾病，过敏症，哮喘，癌症，贫血，血小板减少症或中性粒细胞减少症风险的受试者中是有用的。
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公开(公告)号：US20070224210A1
公开(公告)日：2007-09-27
申请号：US11542845
申请日：2006-10-04
申请人： Arthur Krieg , Grayson Lipford , Ulrike Samulowitz , Jorg Vollmer , Eugen Uhlmann , Marion Jurk , Robert Rankin
发明人： Arthur Krieg , Grayson Lipford , Ulrike Samulowitz , Jorg Vollmer , Eugen Uhlmann , Marion Jurk , Robert Rankin
IPC分类号： A61K39/00
CPC分类号： C12N15/117 , A61K31/70 , A61K2039/55561 , C07H19/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N2310/312 , C12N2310/3125 , C12N2310/313 , C12N2310/315 , C12N2310/336 , C12N2310/345
摘要： The invention relates to a class of soft or semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response.
摘要翻译： 本发明涉及一类可用于刺激免疫应答的软或半软CpG免疫刺激性寡核苷酸。
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公开(公告)号：US20120258140A1
公开(公告)日：2012-10-11
申请号：US13494216
申请日：2012-06-12
申请人： Marion Jurk , Jorg Vollmer
发明人： Marion Jurk , Jorg Vollmer
IPC分类号： A61K39/35 , A61P37/08 , A61K31/7105
CPC分类号： A61K31/7105 , A61K39/39 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/33
摘要： Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7-associated cytokine IFN-α.
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7.发明申请RNA SEQUENCE MOTIFS IN THE CONTEXT OF DEFINED INTERNUCLEOTIDE LINKAGES INDUCING SPECIFIC IMMUNE MODULATORY PROFILES 有权诱导特异性免疫调节剂分析的定义的核苷酸连接物的RNA序列运动公开(公告)号：US20120121648A1
公开(公告)日：2012-05-17
申请号：US13360894
申请日：2012-01-30
申请人： Marion Jurk , Jorg Vollmer
发明人： Marion Jurk , Jorg Vollmer
CPC分类号： A61K31/7105 , A61K39/39 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/33
摘要： Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7-associated cytokine IFN-α.
摘要翻译： 根据本发明提供了含有某些顺序依赖性免疫刺激RNA基序的免疫刺激性聚合物和使用这种免疫刺激性聚合物的方法和含有这些聚合物的组合物。 序列依赖性免疫刺激RNA基序和掺入这种基序的聚合物是TLR7和TLR7相关细胞因子IFN-α的有效和选择性诱导物。
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公开(公告)号：US07956043B2
公开(公告)日：2011-06-07
申请号：US10735592
申请日：2003-12-11
申请人： Arthur M. Krieg , Marion Jurk , Jorg Vollmer , Eugen Uhlmann
发明人： Arthur M. Krieg , Marion Jurk , Jorg Vollmer , Eugen Uhlmann
CPC分类号： C12N15/117 , A61K2039/55561 , C07H21/04 , C12N2310/315
摘要： The invention relates to a class of CpG immunostimulatory oligonucleotides containing a 5′TCG motif or a CG at or near the 5′ end that are useful for stimulating an immune response.
摘要翻译： 本发明涉及一类含有5'5GG基序或在5'端或附近的可用于刺激免疫应答的CpG免疫刺激性寡核苷酸。
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9.发明申请Methods and products related to treatment and prevention of hepatitis c virus infection 失效治疗和预防丙型肝炎病毒感染的方法和产品公开(公告)号：US20060246035A1
公开(公告)日：2006-11-02
申请号：US10532746
申请日：2003-10-29
申请人： Navneet Ahluwalia , Susan Efler , Heather Davis , Jorg Vollmer
发明人： Navneet Ahluwalia , Susan Efler , Heather Davis , Jorg Vollmer
IPC分类号： A61K38/21 , A61K48/00 , A61K31/7056
CPC分类号： A61K31/7088 , A61K31/7056 , A61K38/212 , A61K39/39 , A61K2039/55522 , A61K2039/55561 , C07H21/00 , G01N33/5767 , A61K2300/00
摘要： The invention provides methods for identifying and treating subjects having hepatitis C infections. In some instances, the subjects are those that are non-responsive to non-CpG therapy. Preferably, the subjects are treated with C class CpG immunostimulatory nucleic acids having a semi-soft backbone.
摘要翻译： 本发明提供用于鉴定和治疗患有丙型肝炎感染的受试者的方法。 在某些情况下，受试者是对非CpG治疗无反应的受试者。 优选地，受试者用具有半软骨质骨架的C类CpG免疫刺激核酸处理。
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10.发明申请Methods and products related to treatment and prevention of hepatitis C virus infection 审中-公开治疗和预防丙型肝炎病毒感染的方法和产品公开(公告)号：US20060003962A1
公开(公告)日：2006-01-05
申请号：US11183253
申请日：2005-07-15
申请人： Navneet Ahluwalia , Susan Efler , Heather Davis , Jorg Vollmer
发明人： Navneet Ahluwalia , Susan Efler , Heather Davis , Jorg Vollmer
IPC分类号： A61K48/00
CPC分类号： A61K31/7088 , A61K31/7056 , A61K38/212 , A61K39/39 , A61K2039/55522 , A61K2039/55561 , C07H21/00 , G01N33/5767 , A61K2300/00
摘要： The invention provides methods for identifying and treating subjects having hepatitis C infections. In some instances, the subjects are those that are non-responsive to non-CpG therapy. Preferably, the subjects are treated with C class CpG immunostimulatory nucleic acids having a semi-soft backbone.
摘要翻译： 本发明提供用于鉴定和治疗患有丙型肝炎感染的受试者的方法。 在某些情况下，受试者是对非CpG治疗无反应的受试者。 优选地，受试者用具有半软骨质骨架的C类CpG免疫刺激核酸处理。
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