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公开(公告)号：US06194388B1
公开(公告)日：2001-02-27
申请号：US08386063
申请日：1995-02-07
IPC分类号： A61K4800
CPC分类号： A61K31/70 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68
摘要： Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
摘要翻译： 公开了含有非乙酸化CpG二核苷酸的寡核苷酸和基于其在受试者中刺激免疫应答的能力的治疗效用。 还公开了用于治疗由受试者中由未乙酸化的CpG二核苷酸引发的与免疫系统活化相关的疾病的治疗方法，其包括对所述受试者施用不含非甲基化CpG序列（即甲基化CpG序列或不含CpG序列）的寡核苷酸以超过未甲基化的CpG核酸 用于结合的酸。 进一步公开了含有二核苷酸的甲基化CpG用于反义治疗或体内杂交探针，以及用作抗病毒治疗剂的免疫抑制性寡核苷酸。
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公开(公告)号：US08158592B2
公开(公告)日：2012-04-17
申请号：US11031460
申请日：2005-01-07
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
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公开(公告)号：US08148340B2
公开(公告)日：2012-04-03
申请号：US10888089
申请日：2004-07-09
CPC分类号： A61K31/4706 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12Q1/68
摘要： Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
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公开(公告)号：US08309527B2
公开(公告)日：2012-11-13
申请号：US10789536
申请日：2004-02-26
CPC分类号： A61K31/4706 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12Q1/68
摘要： Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
摘要翻译： 公开了含有非乙酸化CpG二核苷酸的寡核苷酸和基于其在受试者中刺激免疫应答的能力的治疗效用。 还公开了用于治疗由受试者中由未乙酸化的CpG二核苷酸引发的与免疫系统活化相关的疾病的治疗方法，其包括对所述受试者施用不含非甲基化CpG序列（即甲基化CpG序列或不含CpG序列）的寡核苷酸以超过未甲基化的CpG核酸 用于结合的酸。 进一步公开了含有二核苷酸的甲基化CpG用于反义治疗或体内杂交探针，以及用作抗病毒治疗剂的免疫抑制性寡核苷酸。
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公开(公告)号：US08258106B2
公开(公告)日：2012-09-04
申请号：US11598207
申请日：2006-11-10
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
摘要翻译： 公开了含有未甲基化CpG二核苷酸的核酸和基于其刺激免疫应答的能力并将Th2应答重定向到受试者中Th1应答的治疗效用。 公开了治疗特应性疾病，包括特应性皮炎的方法。
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公开(公告)号：US08129351B2
公开(公告)日：2012-03-06
申请号：US11067587
申请日：2005-02-25
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
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公开(公告)号：US07879810B2
公开(公告)日：2011-02-01
申请号：US10956494
申请日：2004-10-01
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
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公开(公告)号：US08114848B2
公开(公告)日：2012-02-14
申请号：US11127797
申请日：2005-05-11
CPC分类号： A61K31/4706 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12Q1/68
摘要： Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
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公开(公告)号：US08058249B2
公开(公告)日：2011-11-15
申请号：US10894862
申请日：2004-07-16
IPC分类号： A61K39/00 , A61K39/38 , A61K39/145 , A61K38/00 , A61K39/02 , A61K39/04 , A61K39/015 , A61K39/012 , A61K39/35 , A61K47/00 , A61K45/00 , A61K9/127 , A61K31/70 , A01N37/18 , A01N43/04
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
摘要翻译： 公开了含有未甲基化CpG二核苷酸的核酸和基于其刺激免疫应答的能力并将Th2应答重定向到受试者中Th1应答的治疗效用。 公开了治疗特应性疾病，包括特应性皮炎的方法。
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公开(公告)号：US07723500B2
公开(公告)日：2010-05-25
申请号：US11503483
申请日：2006-08-11
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
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