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公开(公告)号：US10154995B2
公开(公告)日：2018-12-18
申请号：US15684733
申请日：2017-08-23
发明人： James F. Blake , Adam Cook , Indrani W. Gunawardana , Kevin W. Hunt , Michael Lyon , Andrew T. Metcalf , Peter J. Mohr , David A. Moreno , Brad Newhouse , Li Ren , Tony P. Tang , Allen A. Thomas , Jacob Schwarz , Jane Schmidt , Lewis Gazzard , Huifen Chen
IPC分类号： A61K31/506 , C07D417/14 , C07D405/14 , C07D403/04 , C07D401/14 , C07D471/04 , C07D403/14 , A61K31/4439 , A61K31/444 , A61K45/06
摘要： Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：US09763942B2
公开(公告)日：2017-09-19
申请号：US15197479
申请日：2016-06-29
发明人： James F. Blake , Adam Cook , Indrani W. Gunawardana , Kevin W. Hunt , Michael Lyon , Andrew T. Metcalf , Peter J. Mohr , David A. Moreno , Brad Newhouse , Li Ren , Tony P. Tang , Allen A. Thomas , Jacob Schwarz , Jane Schmidt , Lewis Gazzard , Huifen Chen
IPC分类号： C07D403/14 , C07D471/04 , C07D417/14 , C07D403/04 , C07D401/14 , A61K31/506 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D405/14
CPC分类号： A61K31/506 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04
摘要： Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：US20170348310A1
公开(公告)日：2017-12-07
申请号：US15684733
申请日：2017-08-23
发明人： James F. Blake , Adam Cook , Indrani W. Gunawardana , Kevin W. Hunt , Michael Lyon , Andrew T. Metcalf , Peter J. Mohr , David A. Moreno , Brad Newhouse , Li Ren , Tony P. Tang , Allen A. Thomas , Jacob Schwarz , Jane Schmidt , Lewis Gazzard , Huifen Chen
IPC分类号： A61K31/506 , C07D417/14 , C07D405/14 , C07D403/04 , A61K31/4439 , C07D401/14 , A61K45/06 , A61K31/444 , C07D471/04 , C07D403/14
CPC分类号： A61K31/506 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04
摘要： Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：US20160303126A1
公开(公告)日：2016-10-20
申请号：US15197479
申请日：2016-06-29
发明人： James F. Blake , Adam Cook , Indrani W. Gunawardana , Kevin W. Hunt , Michael Lyon , Andrew T. Metcalf , Peter J. Mohr , David A. Moreno , Brad Newhouse , Li Ren , Tony P. Tang , Allen A. Thomas , Jacob Schwarz , Jane Schmidt , Lewis Gazzard , Huifen Chen
IPC分类号： A61K31/506 , C07D403/14 , C07D471/04 , A61K31/4439 , C07D417/14 , C07D403/04 , C07D401/14 , A61K31/444 , A61K45/06 , C07D405/14
CPC分类号： A61K31/506 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04
摘要： Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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5.发明授权公开(公告)号：US10351575B2
公开(公告)日：2019-07-16
申请号：US14442609
申请日：2013-11-13
申请人： Array BioPharma Inc.
发明人： Shelley Allen , Steven Wade Andrews , James F. Blake , Barbara J. Brandhuber , Julia Haas , Yutong Jiang , Timothy Kercher , Gabrielle R. Kolakowski , Allen A. Thomas , Shannon L. Winski
IPC分类号： C07D401/14 , C07D491/048 , C07D405/14 , C07D231/40 , C07D231/54 , C07D401/12 , C07D403/02 , C07D403/04 , C07D403/14 , C07D405/12 , C07D413/12 , C07D453/02 , C07D231/52 , C07D231/56 , C07D401/04 , C07D409/14 , C07D471/08
摘要： Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
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6.发明授权公开(公告)号：US10889589B2
公开(公告)日：2021-01-12
申请号：US16415575
申请日：2019-05-17
申请人： Array BioPharma Inc.
发明人： Shelley Allen , Steven Wade Andrews , James F. Blake , Barbara J. Brandhuber , Julia Haas , Yutong Jiang , Timothy Kercher , Gabrielle R. Kolakowski , Allen A. Thomas , Shannon L. Winski
IPC分类号： C07D401/14 , C07D405/14 , C07D403/14 , C07D491/048 , C07D231/40 , C07D231/54 , C07D401/12 , C07D403/02 , C07D403/04 , C07D405/12 , C07D413/12 , C07D453/02 , C07D231/52 , C07D231/56 , C07D401/04 , C07D409/14 , C07D471/08
摘要： Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
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7.发明申请公开(公告)号：US20190270749A1
公开(公告)日：2019-09-05
申请号：US16415575
申请日：2019-05-17
申请人： Array BioPharma Inc.
发明人： Shelley Allen , Steven Wade Andrews , James F. Blake , Barbara J. Brandhuber , Julia Haas , Yutong Jiang , Timothy Kercher , Gabrielle R. Kolakowski , Allen A. Thomas , Shannon L. Winski
IPC分类号： C07D491/048 , C07D409/14 , C07D401/14 , C07D231/52 , C07D231/56 , C07D401/04 , C07D453/02 , C07D413/12 , C07D405/12 , C07D403/14 , C07D403/04 , C07D403/02 , C07D401/12 , C07D231/54 , C07D231/40 , C07D405/14 , C07D471/08
摘要： Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
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8.发明申请BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN 审中-公开双酚尿素，硫脲，胍和氰尿嘧啶化合物可用于治疗疼痛公开(公告)号：US20160355521A1
公开(公告)日：2016-12-08
申请号：US14442609
申请日：2013-11-13
申请人： ARRAY BIOPHARMA INC.
发明人： Shelley Allen , Steven Wade Andrews , James F. Blake , Barbara J. Brandhuber , Julia Haas , Yutong Jiang , Timothy Kercher , Gabrielle R. Kolakowski , Allen A. Thomas , Shannon L. Winski
IPC分类号： C07D491/048 , C07D231/56 , C07D405/14 , C07D405/12 , C07D403/14 , C07D471/08 , C07D401/14 , C07D231/52 , C07D403/04 , C07D401/04 , C07D413/12 , C07D409/14 , C07D231/40 , C07D401/12
CPC分类号： C07D491/048 , C07D231/40 , C07D231/52 , C07D231/54 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/02 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D453/02 , C07D471/08
摘要： Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
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9.发明申请N-(ARYLALKYL)-N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS 有权作为TRKA激酶抑制剂的N-（ARYLALKYL）-N'-吡唑并 - 尿素，硫脲，胍和氰基胍化合物公开(公告)号：US20160272592A1
公开(公告)日：2016-09-22
申请号：US14442576
申请日：2013-11-12
申请人： ARRAY BIOPHARMA INC.
发明人： James F. Blake , Barbara J. Brandhuber , Julia Haas , Brad Newhouse , Allen A. Thomas , Shannon L. Winski
IPC分类号： C07D231/52 , C07D401/04 , C07D405/14 , C07D401/14 , C07D231/54 , C07D453/02 , C07D495/04 , C07D413/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D403/04 , C07D231/40
CPC分类号： C07D231/52 , C07D231/38 , C07D231/40 , C07D231/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D453/02 , C07D495/04
摘要： Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C, X, Ra, Rb, Rc, Rd and n are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.
摘要翻译： 式I或其立体异构体，互变异构体或其药学上可接受的盐，溶剂合物或前药的化合物，其中环A，环C，X，R a，R b，R c，R d和n如本文所定义，是TrkA激酶的抑制剂，并且是有用的 治疗可用TrkA激酶抑制剂如疼痛，癌症，炎症/炎性疾病，神经变性疾病，某些感染性疾病，干燥综合征，子宫内膜异位症，糖尿病性周围神经病变，前列腺炎或骨盆疼痛综合征治疗的疾病。
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10.发明授权公开(公告)号：US09969694B2
公开(公告)日：2018-05-15
申请号：US14442576
申请日：2013-11-12
申请人： Array BioPharma Inc.
发明人： James F. Blake , Barbara J. Brandhuber , Julia Haas , Brad Newhouse , Allen A. Thomas , Shannon L. Winski
IPC分类号： C07D231/38 , C07D231/52 , C07D403/12 , C07D401/14 , C07D231/40 , C07D231/54 , C07D401/04 , C07D401/12 , C07D403/04 , C07D413/12 , C07D495/04 , C07D405/12 , C07D405/14 , C07D453/02
CPC分类号： C07D231/52 , C07D231/38 , C07D231/40 , C07D231/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D453/02 , C07D495/04
摘要： Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C, X, Ra, Rb, Rc, Rd and n are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.
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