公开(公告)号：US20210077463A1

公开(公告)日：2021-03-18

申请号：US16772306

申请日：2018-12-17

申请人： PFIZER INC. ,  MERCK PATENT GMBH ,  ARRAY BIOPHARMA INC.

发明人： Christoffel Hendrik Boshoff ,  Rossano Cesari ,  Cristian Massacesi ,  Nuzhat Pathan ,  Patrice A. Lee ,  Shannon L. Winski

IPC分类号： A61K31/4184 ,  A61K39/395 ,  A61K31/5025 ,  A61P35/00 ,  A61K9/00

摘要： This invention relates to a method of treating cancer by administering a combination therapy comprising a combination of a MEK inhibitor and a PD-1 axis binding antagonist, or a combination of a MEK inhibitor and a PARP inhibitor, or a combination of a MEK inhibitor and a PD-1 axis binding antagonist and a PARP inhibitor to a patient in need thereof.

公开(公告)号：US20190270749A1

公开(公告)日：2019-09-05

申请号：US16415575

申请日：2019-05-17

申请人： Array BioPharma Inc.

发明人： Shelley Allen ,  Steven Wade Andrews ,  James F. Blake ,  Barbara J. Brandhuber ,  Julia Haas ,  Yutong Jiang ,  Timothy Kercher ,  Gabrielle R. Kolakowski ,  Allen A. Thomas ,  Shannon L. Winski

IPC分类号： C07D491/048 ,  C07D409/14 ,  C07D401/14 ,  C07D231/52 ,  C07D231/56 ,  C07D401/04 ,  C07D453/02 ,  C07D413/12 ,  C07D405/12 ,  C07D403/14 ,  C07D403/04 ,  C07D403/02 ,  C07D401/12 ,  C07D231/54 ,  C07D231/40 ,  C07D405/14 ,  C07D471/08

摘要： Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.

公开(公告)号：US09809578B2

公开(公告)日：2017-11-07

申请号：US14442495

申请日：2013-11-13

申请人： Array BioPharma Inc.

发明人： Barbara J. Brandhuber ,  Yutong Jiang ,  Gabrielle R. Kolakowski ,  Shannon L. Winski

IPC分类号： C07D403/14 ,  C07D401/14 ,  C07D403/12

CPC分类号： C07D403/14 ,  C07D401/14 ,  C07D403/12

摘要： Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.

公开(公告)号：US20160355521A1

公开(公告)日：2016-12-08

申请号：US14442609

申请日：2013-11-13

申请人： ARRAY BIOPHARMA INC.

发明人： Shelley Allen ,  Steven Wade Andrews ,  James F. Blake ,  Barbara J. Brandhuber ,  Julia Haas ,  Yutong Jiang ,  Timothy Kercher ,  Gabrielle R. Kolakowski ,  Allen A. Thomas ,  Shannon L. Winski

IPC分类号： C07D491/048 ,  C07D231/56 ,  C07D405/14 ,  C07D405/12 ,  C07D403/14 ,  C07D471/08 ,  C07D401/14 ,  C07D231/52 ,  C07D403/04 ,  C07D401/04 ,  C07D413/12 ,  C07D409/14 ,  C07D231/40 ,  C07D401/12

CPC分类号： C07D491/048 ,  C07D231/40 ,  C07D231/52 ,  C07D231/54 ,  C07D231/56 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/02 ,  C07D403/04 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D453/02 ,  C07D471/08

摘要： Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.

公开(公告)号：US20160297796A1

公开(公告)日：2016-10-13

申请号：US14442522

申请日：2013-11-13

申请人： ARRAY BIOPHARMA INC.

发明人： Shelley Allen ,  Steven Wade Andrews ,  James F. Blake ,  Barbara J. Brandhuber ,  Kevin Ronald Condroski ,  Julia Haas ,  Yutong Jiang ,  Timothy Kercher ,  Gabrielle R. Kolakowski ,  Shannon L. Winski

IPC分类号： C07D401/12 ,  C07D417/14 ,  C07D417/12 ,  C07D413/12 ,  C07D401/14 ,  C07D403/12

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： Compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Ring B, and Ring C are as defined herein, and wherein Ring B moiety and the NH—C(═X)—NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.

公开(公告)号：US20160272592A1

公开(公告)日：2016-09-22

申请号：US14442576

申请日：2013-11-12

申请人： ARRAY BIOPHARMA INC.

发明人： James F. Blake ,  Barbara J. Brandhuber ,  Julia Haas ,  Brad Newhouse ,  Allen A. Thomas ,  Shannon L. Winski

IPC分类号： C07D231/52 ,  C07D401/04 ,  C07D405/14 ,  C07D401/14 ,  C07D231/54 ,  C07D453/02 ,  C07D495/04 ,  C07D413/12 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D403/04 ,  C07D231/40

CPC分类号： C07D231/52 ,  C07D231/38 ,  C07D231/40 ,  C07D231/54 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D453/02 ,  C07D495/04

摘要： Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C, X, Ra, Rb, Rc, Rd and n are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.

摘要翻译： 式I或其立体异构体，互变异构体或其药学上可接受的盐，溶剂合物或前药的化合物，其中环A，环C，X，R a，R b，R c，R d和n如本文所定义，是TrkA激酶的抑制剂，并且是有用的 治疗可用TrkA激酶抑制剂如疼痛，癌症，炎症/炎性疾病，神经变性疾病，某些感染性疾病，干燥综合征，子宫内膜异位症，糖尿病性周围神经病变，前列腺炎或骨盆疼痛综合征治疗的疾病。

公开(公告)号：US20180179182A1

公开(公告)日：2018-06-28

申请号：US15851418

申请日：2017-12-21

申请人： Array BioPharma Inc.

发明人： Shelley Allen ,  Barbara J. Brandhuber ,  Timothy Kercher ,  Gabrielle R. Kolakowski ,  Shannon L. Winski

IPC分类号： C07D401/14 ,  C07D403/12 ,  C07D403/14

CPC分类号： C07D401/14 ,  A61P29/00 ,  A61P35/00 ,  C07D403/12 ,  C07D403/14

摘要： Compounds useful for the treatment of pain or cancer in a mammal.

公开(公告)号：US09822118B2

公开(公告)日：2017-11-21

申请号：US14442503

申请日：2013-11-13

申请人： Array BioPharma Inc.

发明人： Shelley Allen ,  Barbara J. Brandhuber ,  Kevin Ronald Condroski ,  Lily Huang ,  Timothy Kercher ,  Shannon L. Winski

IPC分类号： C07D487/04 ,  C07D231/56 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04 ,  C07D403/12 ,  C07D519/00

CPC分类号： C07D487/04 ,  C07D231/56 ,  C07D403/12 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04 ,  C07D519/00

摘要： Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.

公开(公告)号：US09790210B2

公开(公告)日：2017-10-17

申请号：US14442604

申请日：2013-11-12

申请人： Array BioPharma Inc.

发明人： Steven Wade Andrews ,  James F. Blake ,  Barbara J. Brandhuber ,  Timothy Kercher ,  Shannon L. Winski

IPC分类号： C07D231/00 ,  C07D403/00 ,  C07D401/00 ,  C07D211/72 ,  C07D413/00 ,  C07D405/12 ,  C07D403/12 ,  C07D401/14 ,  C07D231/40 ,  C07D231/44 ,  C07D401/04 ,  C07D413/12 ,  C07D231/52 ,  C07D401/12 ,  C07D405/04 ,  A61K31/4155

CPC分类号： C07D405/12 ,  A61K31/4155 ,  C07D231/40 ,  C07D231/44 ,  C07D231/52 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/04 ,  C07D413/12

摘要： Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.

公开(公告)号：US20160355517A1

公开(公告)日：2016-12-08

申请号：US14442503

申请日：2013-11-13

申请人： ARRAY BIOPHARMA INC.

发明人： Shelley Allen ,  Barbara J. Brandhuber ,  Kevin Ronald Condroski ,  Lily Huang ,  Timothy Kercher ,  Shannon L. Winski

IPC分类号： C07D487/04 ,  C07D519/00 ,  C07D403/12 ,  C07D471/04

CPC分类号： C07D487/04 ,  C07D231/56 ,  C07D403/12 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04 ,  C07D519/00

摘要： Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.