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公开(公告)号：US20240277858A1
公开(公告)日：2024-08-22
申请号：US18174751
申请日：2023-02-27
发明人： Russell C. Addis , Zhanna Druzina , Robert Kolakowski , Swapnil Kulkarni , Steven G. Nadler , Karyn O'Neil , Yao Xin
IPC分类号： A61K47/64 , A61K31/7088 , C07K14/435 , C12N15/113
CPC分类号： A61K47/6435 , A61K31/7088 , C07K14/435 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/3513 , C12N2320/32
摘要： The present disclosure relates to polypeptides, such as fibronectin type III (FN3) domains that can bind CD71, their conjugates, isolated nucleotides encoding the molecules, vectors, host-cells, as well as methods of making and using the same.
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公开(公告)号：US20240175034A1
公开(公告)日：2024-05-30
申请号：US18490450
申请日：2023-10-19
发明人： Swapnil Kulkarni , Thomas Zengeya , Sukumar Sakamuri , Jacqueline Lee , Steven G. Nadler , Meera Ramanujam , Karyn T. O’Neil , Stephen Anderson
IPC分类号： C12N15/113 , A61P37/06
CPC分类号： C12N15/1138 , A61P37/06 , C12N2310/14 , C12N2310/312 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3513
摘要： The present disclosure relates to compositions, such as siRNA molecules and FN3 domains conjugated to the same, as well as methods of making and using the molecules.
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公开(公告)号：US20210145976A1
公开(公告)日：2021-05-20
申请号：US17070020
申请日：2020-10-14
发明人： Russell C. Addis , Zhanna Druzina , Robert Kolakowski , Swapnil Kulkarni , Steven G. Nadler , Karyn O'Neil , Yao Xin
IPC分类号： A61K47/64 , C07K14/435 , A61K31/7088 , C12N15/113
摘要： The present disclosure relates to polypeptides, such as fibronectin type III (FN3) domains that can bind CD71, their conjugates, isolated nucleotides encoding the molecules, vectors, host-cells, as well as methods of making and using the same.
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公开(公告)号：US20210108201A1
公开(公告)日：2021-04-15
申请号：US17070337
申请日：2020-10-14
发明人： Russell C. Addis , Zhanna Druzina , Robert Kolakowski , Swapnil Kulkarni , Steven G. Nadler , Karyn O'Neil , Yao Xin
IPC分类号： C12N15/113 , C07K14/78 , A61K31/713 , A61K47/64
摘要： The present disclosure relates to compositions, such as siRNA molecules and FN3 domains conjugated to the same, as well as methods of making and using the molecules.
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公开(公告)号：US12037379B2
公开(公告)日：2024-07-16
申请号：US17720422
申请日：2022-04-14
发明人： Russell C. Addis , Zhanna Druzina , Robert V. Kolakowski , Steven G. Nadler , Karyn T. O'Neil , Yao Xin
IPC分类号： C07K14/78 , A61K31/7125 , A61K47/64 , C12N15/113
CPC分类号： C07K14/78 , A61K31/7125 , A61K47/6435 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/3513 , C12N2320/32
摘要： The present disclosure relates to polypeptides, such as fibronectin type III (FN3) domains that can bind CD71, their conjugates, isolated nucleotides encoding the molecules, vectors, host-cells, as well as methods of making and using the same.
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公开(公告)号：US11781138B2
公开(公告)日：2023-10-10
申请号：US17070337
申请日：2020-10-14
发明人： Russell C. Addis , Zhanna Druzina , Robert Kolakowski , Swapnil Kulkarni , Steven G. Nadler , Karyn O'Neil , Yao Xin
IPC分类号： C12N15/113 , A61K47/64 , A61K31/713 , C07K14/78
CPC分类号： C12N15/113 , A61K31/713 , A61K47/6435 , C07K14/78 , C12N2310/11 , C12N2320/32
摘要： The present disclosure relates to compositions, such as siRNA molecules and FN3 domains conjugated to the same, as well as methods of making and using the molecules.
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公开(公告)号：US11628222B2
公开(公告)日：2023-04-18
申请号：US17070020
申请日：2020-10-14
发明人： Russell C. Addis , Zhanna Druzina , Robert Kolakowski , Swapnil Kulkarni , Steven G. Nadler , Karyn O'Neil , Yao Xin
IPC分类号： A61K47/64 , A61K31/7088 , C07K14/435 , C12N15/113
摘要： The present disclosure relates to polypeptides, such as fibronectin type III (FN3) domains that can bind CD71, their conjugates, isolated nucleotides encoding the molecules, vectors, host-cells, as well as methods of making and using the same.
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