公开(公告)号：US20160136294A1

公开(公告)日：2016-05-19

申请号：US15001197

申请日：2016-01-19

申请人： Applied Nanosystems B.V.

发明人： Cornelis Johannes Leenhouts ,  Maarten Leonardus Van Roosmalen ,  Tjibbe Bosma

IPC分类号： A61K47/48 ,  A61K39/385 ,  C07K16/18

CPC分类号： C07K16/18 ,  A61K39/385 ,  A61K47/68 ,  A61K2039/541 ,  A61K2039/55555 ,  A61K2039/6056 ,  A61K2039/6068 ,  A61K2039/622 ,  C07K14/335 ,  C07K2319/70 ,  C07K2319/705

摘要： The disclosure relates to the areas of immunology and vaccine delivery. More specifically, it relates to a bacterial vaccine delivery technology with built-in immunostimulatory properties which allow the immobilization of any antigen of interest, without prior antigen modification. Provided is an antigen-loaded immunogenic carrier complex comprising at least one bifunctional polypeptide attached to an immunogenic carrier, the bifunctional polypeptide comprising a peptidoglycan binding domain (PBD) through which the polypeptide is attached to the carrier, fused to an antigen binding domain (ABD) to which at least one antigen of interest is bound. Also described is a pharmaceutical (e.g., vaccine) composition comprising an antigen-loaded immunogenic carrier complex.