公开(公告)号：US12269811B2

公开(公告)日：2025-04-08

申请号：US18359467

申请日：2023-07-26

Applicant: Amgen Inc.

Inventor： Sebastien Caille ,  Kyle Quasdorf ,  Philipp C. Roosen ,  Xianqing Shi ,  Andrew Cosbie ,  Fang Wang ,  Zufan Wu ,  Archana Neergunda ,  Bin Peter Quan ,  Lianxiu Guan

IPC: C07D295/205 ,  C07D213/75 ,  C07D241/04 ,  C07D401/12

Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates. (1)

公开(公告)号：US11753394B2

公开(公告)日：2023-09-12

申请号：US17324867

申请日：2021-05-19

Applicant: AMGEN INC.

Inventor： Sebastien Caille ,  Kyle Quasdorf ,  Philipp C. Roosen ,  Xianqing Shi ,  Andrew Cosbie ,  Fang Wang ,  Zufan Wu ,  Archana Neergunda ,  Bin Peter Quan ,  Lianxiu Guan

IPC: C07D401/12 ,  C07D241/04

CPC classification number: C07D401/12 ,  C07D241/04

Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.

公开(公告)号：US20210371397A1

公开(公告)日：2021-12-02

申请号：US17324867

申请日：2021-05-19

Applicant: AMGEN INC.

Inventor： Sebastien Caille ,  Kyle Quasdorf ,  Philipp C. Roosen ,  Xianqing Shi ,  Andrew Cosbie ,  Fang Wang ,  Zufan Wu ,  Archana Neergunda ,  Bin Peter Quan ,  Lianxiu Guan

IPC: C07D401/12 ,  C07D241/04

Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.

公开(公告)号：US11040956B2

公开(公告)日：2021-06-22

申请号：US16607940

申请日：2018-06-29

Applicant: AMGEN INC.

Inventor： Sebastien Caille ,  Kyle Quasdorf ,  Philipp Roosen ,  Xianqing Shi ,  Andrew Cosbie ,  Fang Wang ,  Zufan Wu ,  Archana Neergunda ,  Bin Peter Quan ,  Lianxiu Guan

IPC: C07D295/205 ,  C07D213/75 ,  C07D401/12 ,  C07D241/04

Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates. (I)

公开(公告)号：US20200308143A1

公开(公告)日：2020-10-01

申请号：US16607940

申请日：2018-06-29

Applicant: AMGEN INC.

Inventor： Sebastien Caille ,  Kyle Quasdorf ,  Philipp Roosen ,  Xianqing Shi ,  Andrew Cosbie ,  Fang Wang ,  Zufan Wu ,  Archana Neergunda ,  Bin Peter Quan ,  Lianxiu Guan

IPC: C07D401/12 ,  C07D241/04

Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates. (I)