公开(公告)号：US11685772B2

公开(公告)日：2023-06-27

申请号：US18066251

申请日：2022-12-14

Applicant: AMGEN INC.

Inventor： Brian D. Follstad ,  Rebecca E. McCoy ,  Arvia E. Morris

IPC: C07K16/00 ,  C12N5/00 ,  C12P21/02 ,  C12P21/00

CPC classification number: C07K16/00 ,  C12N5/0037 ,  C12P21/00 ,  C12P21/02 ,  C07K2317/14 ,  C12N2500/32 ,  C12N2510/02 ,  C12N2523/00

Abstract: The invention provides a method for culturing mammalian cells. The method provides greater control over cell growth to achieve high product titer cell cultures.

公开(公告)号：US11827692B2

公开(公告)日：2023-11-28

申请号：US18180828

申请日：2023-03-08

Applicant: AMGEN INC.

Inventor： Brian D. Follstad ,  Rebecca E. McCoy ,  Arvia E. Morris

IPC: C07K16/00 ,  C12N5/00 ,  C12P21/02 ,  C07K1/14 ,  C12N5/073 ,  C12P21/00

CPC classification number: C07K16/00 ,  C07K1/14 ,  C12N5/0037 ,  C12N5/0604 ,  C12P21/00 ,  C12P21/02 ,  C07K2317/14 ,  C12N2500/02 ,  C12N2500/99 ,  C12N2510/02 ,  C12N2523/00

Abstract: The invention provides a method for culturing mammalian cells. The method provides greater control over cell o growth to achieve high product titer cell cultures.

公开(公告)号：US11673941B2

公开(公告)日：2023-06-13

申请号：US17018564

申请日：2020-09-11

Applicant: Amgen Inc.

Inventor： Brian D. Follstad ,  Rebecca E. McCoy ,  Arvia E. Morris

IPC: C07K16/00 ,  C12P21/00 ,  C12N5/00 ,  C12P21/02

CPC classification number: C07K16/00 ,  C12N5/0037 ,  C12P21/00 ,  C12P21/02 ,  C07K2317/14 ,  C12N2500/32 ,  C12N2510/02 ,  C12N2523/00

Abstract: The invention provides a method for culturing mammalian cells. The method provides greater control over cell growth to achieve high product titer cell cultures.

公开(公告)号：US11634476B2

公开(公告)日：2023-04-25

申请号：US17018557

申请日：2020-09-11

Applicant: Amgen Inc.

Inventor： Brian D. Follstad ,  Rebecca E. McCoy ,  Arvia E. Morris

IPC: C07K16/00 ,  C12N5/00 ,  C12P21/02 ,  C12P21/00

Abstract: The invention provides a method for culturing mammalian cells. The method provides greater control over cell growth to achieve high product titer cell cultures.

公开(公告)号：US09388447B2

公开(公告)日：2016-07-12

申请号：US14821574

申请日：2015-08-07

Applicant: Amgen Inc.

Inventor： Matthew I. Jerums ,  Amanda Kano ,  Henry Lin ,  Shun Luo ,  Jian Wu ,  Rebecca E. McCoy ,  Arvia E. Morris

IPC: C12N5/077 ,  C12P21/00 ,  C12N5/00

CPC classification number: C12P21/00 ,  C12N5/0037 ,  C12N5/0043 ,  C12N2500/32 ,  C12N2510/02 ,  C12N2511/00

Abstract: The present invention relates to methods for mammalian cell culture. The methods make use of independent tyrosine and cystine feed streams.