公开(公告)号：US20230365970A1

公开(公告)日：2023-11-16

申请号：US18361363

申请日：2023-07-28

Applicant: Aligos Therapeutics, Inc.

Inventor： Leonid Beigelman ,  Vivek Kumar Rajwanshi ,  Markus Hossbach ,  Rajendra K. Pandey ,  Jin Hong ,  Laxman Eltepu ,  Saul Martinez Montero ,  N. Tilani S. De Costa

IPC: C12N15/113 ,  A61K31/713 ,  A61K45/06 ,  A61P31/20

CPC classification number: C12N15/1131 ,  A61K31/713 ,  A61K45/06 ,  A61P31/20 ,  C12N2310/351 ,  C12N2310/315 ,  C12N2310/14 ,  C12N2320/31 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/322

Abstract: Disclosed herein are short interfering nucleic acid (siNA) molecules comprising modified nucleotides and uses thereof. The siNA molecules may be double stranded and comprise modified nucleotides selected from 2′-O-methyl nucleotides and 2′-fluoro nucleotides. Further disclosed herein are siNA molecules comprising (a) a phosphorylation blocker, conjugated moiety, or 5′-stabilized end cap; and (b) a short interfering nucleic acid (siNA).

公开(公告)号：US11549110B2

公开(公告)日：2023-01-10

申请号：US17672268

申请日：2022-02-15

Applicant: Aligos Therapeutics, Inc.

Inventor： Leonid Beigelman ,  Vivek Kumar Rajwanshi ,  Markus Hossbach ,  Rajendra K. Pandey ,  Jin Hong ,  Laxman Eltepu ,  Saul Martinez Montero ,  N. Tilani S. De Costa

IPC: C12N15/113 ,  A61P31/20 ,  A61K31/713 ,  A61K45/06

Abstract: Disclosed herein are short interfering nucleic acid (siNA) molecules comprising modified nucleotides and uses thereof. The siNA molecules may be double stranded and comprise modified nucleotides selected from 2′-O-methyl nucleotides and 2′-fluoro nucleotides. Further disclosed herein are siNA molecules comprising (a) a phosphorylation blocker, conjugated moiety, or 5′-stabilized end cap; and (b) a short interfering nucleic acid (siNA).

公开(公告)号：US12129469B2

公开(公告)日：2024-10-29

申请号：US18361363

申请日：2023-07-28

Applicant: Aligos Therapeutics, Inc.

Inventor： Leonid Beigelman ,  Vivek Kumar Rajwanshi ,  Markus Hossbach ,  Rajendra K. Pandey ,  Jin Hong ,  Laxman Eltepu ,  Saul Martinez Montero ,  N. Tilani S. De Costa

IPC: C12N15/113 ,  A61K31/713 ,  A61K45/06 ,  A61P31/20

CPC classification number: C12N15/1131 ,  A61K31/713 ,  A61K45/06 ,  A61P31/20 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/351 ,  C12N2320/31

Abstract: Disclosed herein are short interfering nucleic acid (siNA) molecules comprising modified nucleotides and uses thereof. The siNA molecules may be double stranded and comprise modified nucleotides selected from 2′-O-methyl nucleotides and 2′-fluoro nucleotides. Further disclosed herein are siNA molecules comprising (a) a phosphorylation blocker, conjugated moiety, or 5′-stabilized end cap; and (b) a short interfering nucleic acid (siNA).

公开(公告)号：US20230332153A1

公开(公告)日：2023-10-19

申请号：US18059561

申请日：2022-11-29

Applicant: Aligos Therapeutics, Inc.

Inventor： Leonid Beigelman ,  Vivek Kumar Rajwanshi ,  Markus Hossbach ,  Rajendra K. Pandey ,  Jin Hong ,  Laxman Eltepu ,  Saul Martinez Montero ,  N. Tilani S. De Costa

IPC: C12N15/113 ,  A61K31/713 ,  A61K45/06 ,  A61P31/20

CPC classification number: C12N15/1131 ,  A61K31/713 ,  A61K45/06 ,  A61P31/20 ,  C12N2310/351 ,  C12N2310/315 ,  C12N2310/14 ,  C12N2320/31 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/322

Abstract: Disclosed herein are short interfering nucleic acid (siNA) molecules comprising modified nucleotides and uses thereof. The siNA molecules may be double stranded and comprise modified nucleotides selected from 2′-O-methyl nucleotides and 2′-fluoro nucleotides. Further disclosed herein are siNA molecules comprising (a) a phosphorylation blocker, conjugated moiety, or 5′-stabilized end cap; and (b) a short interfering nucleic acid (siNA).

公开(公告)号：US20220364096A1

公开(公告)日：2022-11-17

申请号：US17194079

申请日：2021-03-05

Applicant: Aligos Therapeutics, Inc.

Inventor： Leonid Beigelman ,  Vivek Kumar Rajwanshi ,  Markus Hossbach ,  Rajendra K. Pandey ,  Jin Hong ,  Laxman Eltepu ,  Saul Martinez Montero ,  N. Tilani S. De Costa

IPC: C12N15/113 ,  A61K45/06 ,  A61K31/713 ,  A61P31/20

Abstract: Disclosed herein are short interfering nucleic acid (siNA) molecules comprising modified nucleotides and uses thereof. The siNA molecules may be double stranded and comprise modified nucleotides selected from 2′-O-methyl nucleotides and 2′-fluoro nucleotides. Further disclosed herein are siNA molecules comprising (a) a phosphorylation blocker, conjugated moiety, or 5′-stabilized end cap; and (b) a short interfering nucleic acid (siNA).

公开(公告)号：US11466274B2

公开(公告)日：2022-10-11

申请号：US16887063

申请日：2020-05-29

Applicant: Aligos Therapeutics, Inc.

Inventor： Leonid Beigelman ,  Rajendra K. Pandey ,  Vivek Kumar Rajwanshi ,  David Bernard Smith ,  Jin Hong

IPC: C12N15/11 ,  C12N15/113 ,  A61P31/20 ,  A61K31/7125

Abstract: The disclosure includes antisense oligonucleotides, including gapmer antisense oligonucleotides, along with methods of making and use, e.g., against HBV.

公开(公告)号：US20210189392A1

公开(公告)日：2021-06-24

申请号：US17117494

申请日：2020-12-10

Applicant: Aligos Therapeutics, Inc.

Inventor： Leonid Beigelman ,  Rajendra Pandey ,  Vivek Kumar Rajwanshi ,  David Bernard Smith ,  Lawrence M. Blatt ,  Jin Hong ,  Megan Elizabeth Fitzgerald

IPC: C12N15/113

Abstract: Various embodiments provide STOPS™ polymers that are S-antigen transport inhibiting oligonucleotide polymers, processes for making them and methods of using them to treat diseases and conditions. In some embodiments the STOPS™ modified oligonucleotides include an at least partially phosphorothioated sequence of alternating A and C units having modifications as described herein. The sequence independent antiviral activity against hepatitis B of embodiments of STOPS™ modified oligonucleotides, as determined by HBsAg Secretion Assay, is an EC50 that is less than 100 nM.

公开(公告)号：US20230159929A1

公开(公告)日：2023-05-25

申请号：US17939896

申请日：2022-09-07

Applicant: Aligos Therapeutics, Inc.

Inventor： Leonid Beigelman ,  Vivek Kumar Rajwanshi ,  Markus Hossbach ,  Rajendra K. Pandey ,  Jin Hong ,  Laxman Eltepu ,  Saul Martinez Montero ,  N. Tilani S. De Costa

IPC: C12N15/113 ,  A61P31/20

CPC classification number: C12N15/113 ,  A61P31/20 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/314

Abstract: Described are short interfering nucleic acid (siNA) molecules comprising modified nucleotides, compositions, and methods and uses thereof.

公开(公告)号：US20220177888A1

公开(公告)日：2022-06-09

申请号：US17672268

申请日：2022-02-15

Applicant: Aligos Therapeutics, Inc.

Inventor： Leonid Beigelman ,  Vivek Kumar Rajwanshi ,  Markus Hossbach ,  Rajendra K. Pandey ,  Jin Hong ,  Laxman Eltepu ,  Saul Martinez Montero ,  N. Tilani S. De Costa

IPC: C12N15/113 ,  A61P31/20 ,  A61K31/713 ,  A61K45/06

Abstract: Disclosed herein are short interfering nucleic acid (siNA) molecules comprising modified nucleotides and uses thereof. The siNA molecules may be double stranded and comprise modified nucleotides selected from 2′-O-methyl nucleotides and 2′-fluoro nucleotides. Further disclosed herein are siNA molecules comprising (a) a phosphorylation blocker, conjugated moiety, or 5′-stabilized end cap; and (b) a short interfering nucleic acid (siNA).

公开(公告)号：US20220160748A1

公开(公告)日：2022-05-26

申请号：US17455528

申请日：2021-11-18

Applicant: Aligos Therapeutics, Inc.

Inventor： Leonid Beigelman ,  Megan Elizabeth Fitzgerald ,  Rajendra Pandey ,  Jin Hong ,  Vivek Kumar Rajwanshi ,  David Bernard Smith ,  Lawrence M. Blatt

IPC: A61K31/7088 ,  A61K47/54 ,  A61P1/16

Abstract: Disclosed herein is an oligonucleotide conjugate or complex thereof, comprising a modified oligonucleotide having sequence independent antiviral activity against hepatitis B, a liver targeting agent, and a linker connecting the liver targeting agent to a 3′ end and/or a 5′ end of the modified oligonucleotide or complex thereof. The oligonucleotide conjugate may be incorporated into a pharmaceutical composition for treating a liver disease or disorder such as hepatitis B.