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1.发明申请公开(公告)号：US20160361254A1
公开(公告)日：2016-12-15
申请号：US15245496
申请日：2016-08-24
申请人： Alcon Research Ltd.
CPC分类号： A61K9/0051 , A61K9/0019 , A61K9/0048 , A61K38/00 , A61K38/16 , A61K47/36 , A61K47/42
摘要： The present invention is directed to the provision of an ophthalmic composition suitable for intravitreal injection. The composition includes an amount of complexing agent that reacts with one or more endogenous components (e.g., hyaluronic acid) in the eye to form a mass of enhanced viscosity. This mass can aid in creating a desirable release profile of therapeutic agent.
摘要翻译： 本发明涉及提供适于玻璃体内注射的眼用组合物。 组合物包含一定量的与眼睛中的一种或多种内源组分（例如透明质酸）反应以形成增强粘度的质量的络合剂。 该物质可有助于产生理想的释放曲线的治疗剂。
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公开(公告)号：US09446093B2
公开(公告)日：2016-09-20
申请号：US14057125
申请日：2013-10-18
申请人： Alcon Research Ltd.
CPC分类号： A61K9/0051 , A61K9/0019 , A61K9/0048 , A61K38/00 , A61K38/16 , A61K47/36 , A61K47/42
摘要： The present invention is directed to the provision of an ophthalmic composition suitable for intravitreal injection. The composition includes an amount of complexing agent that reacts with one or more endogenous components (e.g., hyaluronic acid) in the eye to form a mass of enhanced viscosity. This mass can aid in creating a desirable release profile of therapeutic agent.
摘要翻译： 本发明涉及提供适于玻璃体内注射的眼用组合物。 组合物包含一定量的与眼睛中的一种或多种内源组分（例如透明质酸）反应以形成增强粘度的质量的络合剂。 该物质可有助于产生理想的释放曲线的治疗剂。
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3.发明申请STABILIZED PHARMACEUTICAL SUB-MICRON SUSPENSIONS AND METHODS OF FORMING SAME 审中-公开稳定的药用亚微米悬浮液及其形成方法公开(公告)号：US20140294970A1
公开(公告)日：2014-10-02
申请号：US14302122
申请日：2014-06-11
申请人： Alcon Research, Ltd.
IPC分类号： A61K47/38 , A61K31/416 , A61K31/165 , A61K9/14
CPC分类号： A61K31/165 , A61K9/0048 , A61K9/10 , A61K9/14 , A61K9/1652 , A61K9/1682 , A61K31/416 , A61K47/38
摘要： The present invention is directed to a pharmaceutical submicron suspension and a method of forming the submicron suspension. The submicron suspension is useful for delivery of relatively hydrophobic and/or low solubility therapeutic agent. The submicron suspension and method of forming the submicron suspension typically employ a polymeric material that aids in preventing aggregation of the therapeutic agent.
摘要翻译： 本发明涉及药物亚微米悬浮液和形成亚微米悬浮液的方法。 亚微米悬浮液可用于递送相对疏水和/或低溶解度的治疗剂。 亚微米悬浮液和形成亚微米悬浮液的方法通常使用有助于防止治疗剂聚集的聚合物材料。
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4.发明申请公开(公告)号：US20140094419A1
公开(公告)日：2014-04-03
申请号：US14057125
申请日：2013-10-18
申请人： Alcon Research Ltd.
CPC分类号： A61K9/0051 , A61K9/0019 , A61K9/0048 , A61K38/00 , A61K38/16 , A61K47/36 , A61K47/42
摘要： The present invention is directed to the provision of an ophthalmic composition suitable for intravitreal injection. The composition includes an amount of complexing agent that reacts with one or more endogenous components (e.g., hyaluronic acid) in the eye to form a mass of enhanced viscosity. This mass can aid in creating a desirable release profile of therapeutic agent.
摘要翻译： 本发明涉及提供适于玻璃体内注射的眼用组合物。 组合物包含一定量的与眼睛中的一种或多种内源组分（例如透明质酸）反应以形成增强粘度的质量的络合剂。 该物质可有助于产生理想的释放曲线的治疗剂。
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公开(公告)号：US20170216228A1
公开(公告)日：2017-08-03
申请号：US15493232
申请日：2017-04-21
申请人： Alcon Research, Ltd.
IPC分类号： A61K31/165 , A61K9/00 , A61K9/16
CPC分类号： A61K31/165 , A61K9/0048 , A61K9/10 , A61K9/14 , A61K9/1652 , A61K9/1682 , A61K31/416 , A61K47/38
摘要： The present invention is directed to a pharmaceutical submicron suspension and a method of forming the submicron suspension. The submicron suspension is useful for delivery of relatively hydrophobic and/or low solubility therapeutic agent. The submicron suspension and method of forming the submicron suspension typically employ a polymeric material that aids in preventing aggregation of the therapeutic agent.
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