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公开(公告)号：US11464775B2
公开(公告)日：2022-10-11
申请号：US16639086
申请日：2018-08-15
发明人： Giovanni Cianchetta , Charles Kung , Tao Liu , Anil Kumar Padyana , Zhihua Sui , Zhenwei Cai , Dawei Cui , Jingjing Ji
IPC分类号： A61K31/5025 , A61K31/506 , A61K31/519 , C07D241/36 , C07D513/14 , A61K45/06
摘要： Described herein are methods of using compounds of Formula (I) to modulate PKM2 activity in a subject. These compounds are represented by Formula (I): wherein R1, R2, L1, and L2 are as defined herein.
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公开(公告)号：US20200207785A1
公开(公告)日：2020-07-02
申请号：US16639081
申请日：2018-08-15
发明人： Giovanni Cianchetta , Tao Liu , Anil Kumar Padyana , Zhihua Sui , Zhenwei Cai , Dawei Cui , Jingjing Ji
IPC分类号： C07D513/14 , C07D241/36
摘要： Described herein are compounds that activate pyruvate kinase, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I) wherein R1, R2, Ra, Rb, Rj, Rk, and Q are as defined herein
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公开(公告)号：US20200085832A1
公开(公告)日：2020-03-19
申请号：US16692217
申请日：2019-11-22
发明人： Zhihua Sui , Robert Zahler
IPC分类号： A61K31/53 , A61K45/06 , C07D401/04 , A61P35/00 , A61N5/10
摘要： Provided are deuterated analogs of a compound and methods of using such deuterated analogs for treating a brain tumor in a patient in need thereof; the treatment comprising administering to the patient a deuterated compound described herein. The deuterated compound may be administered in combination with radiation therapy and/or an additional therapeutic agent.
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公开(公告)号：US20240276957A1
公开(公告)日：2024-08-22
申请号：US17616790
申请日：2020-06-05
发明人： Giovanni Cianchetta , Peng Liu , Shengfang Jin , Brian Christopher Shook , Zhihua Sui , Kai Lu , Barden Chan , Gavin Whissell
IPC分类号： A01K67/0275 , C12N9/10 , C12N9/22 , C12N15/11 , C12N15/85
CPC分类号： A01K67/0275 , C12N9/1029 , C12N9/22 , C12N15/11 , C12N15/8509 , C12Y203/01037 , A01K2217/054 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , C12N2015/8536 , C12N2310/20 , C12N2800/80
摘要： Described herein is a compound of Formula I or a pharmaceutically acceptable salt thereof: wherein Ring A R1, R2, a, b, and n are as defined herein. Also described is a method of treating a subject having a disorder in need of treatment, comprising inhibiting aminolevulinic acid synthase 2 (ALAS2) in the subject by administering a compound of Formula (I) or a pharmaceutically acceptable salt thereof. Disorders that are of particular interest are blood disorders, such as porphyria and anemia.
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公开(公告)号：US20180079753A1
公开(公告)日：2018-03-22
申请号：US15691408
申请日：2017-08-30
发明人： Zenon D. Konteatis , Zhihua Sui , Jeremy M. Travins , Zhixiong Ye
IPC分类号： C07D487/04 , C07D519/00 , C07F9/6561
CPC分类号： C07D487/04 , C07D519/00 , C07F9/6561
摘要： The present disclosure provides MAT2A inhibitor compounds that are useful as therapeutic agents for treating malignancies, and wherein the compounds conform to general formula (IA): wherein RA, RB, RC, RD, and RE are defined herein.
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公开(公告)号：US11590132B2
公开(公告)日：2023-02-28
申请号：US16639081
申请日：2018-08-15
发明人： Giovanni Cianchetta , Tao Liu , Anil Kumar Padyana , Zhihua Sui , Zhenwei Cai , Dawei Cui , Jingjing Ji
IPC分类号： C07D513/04 , A61K31/5025 , A61P7/06 , A61P7/08 , A61P3/10 , A61P35/00 , A61K31/506 , A61K31/519 , C07D241/36 , C07D513/14 , A61K45/06
摘要： Described herein are compounds that activate pyruvate kinase, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I) wherein R1, R2, Ra, Rb, Rj, Rk, and Q are as defined herein.
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公开(公告)号：US20220395503A1
公开(公告)日：2022-12-15
申请号：US17744806
申请日：2022-05-16
发明人： Giovanni Cianchetta , Tao Liu , Anil Kumar Padyana , Zhihua Sui , Zhenwei Cai , Dawei Cui , Jingjing Ji
IPC分类号： A61K31/5025 , A61K31/506 , A61K31/519 , C07D241/36 , C07D513/14
摘要： Described herein are compounds that activate pyruvate kinase R, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I): wherein R1, R2, L1, and L2 are as defined herein.
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公开(公告)号：US20220233541A1
公开(公告)日：2022-07-28
申请号：US17586777
申请日：2022-01-27
发明人： Giovanni Cianchetta , Charles Kung , Tao Liu , Anil Kumar Padyana , Zhihua Sui , Zhenwei Cai , Dawei Cui , Jingjing Ji
IPC分类号： A61K31/5025 , A61K31/506 , A61K31/519 , C07D241/36 , C07D513/14
摘要： Described herein are methods of using compounds of Formula (I) to modulate PKM2 activity in a subject. These compounds are represented by Formula (I): wherein R1, R2, L1, and L2 are as defined herein.
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公开(公告)号：US20210077490A1
公开(公告)日：2021-03-18
申请号：US16952257
申请日：2020-11-19
发明人： Giovanni Cianchetta , Tao Liu , Anil Kumar Padyana , Zhihua Sui , Zhenwei Cai , Dawei Cui , Jingjing Ji
IPC分类号： A61K31/5025 , A61K31/506 , A61K31/519 , C07D241/36 , C07D513/14
摘要： Described herein are compounds that activate pyruvate kinase, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I) wherein R1, R2, Ra, Rb, Rj, Rk, and Q are as defined herein.
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公开(公告)号：US10800782B2
公开(公告)日：2020-10-13
申请号：US16219735
申请日：2018-12-13
发明人： Zenon D. Konteatis , Zhihua Sui , Jeremy M. Travins , Zhixiong Ye
IPC分类号： C07D487/04 , C07D519/00 , C07F9/6561
摘要： The present disclosure provides MAT2A inhibitor compounds that are useful as therapeutic agents for treating malignancies, and wherein the compounds conform to general formula (IA): wherein RA, RB, RC, RD, and RE are defined herein.
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