公开(公告)号：US11464775B2

公开(公告)日：2022-10-11

申请号：US16639086

申请日：2018-08-15

申请人： Agios Pharmaceuticals, Inc.

发明人： Giovanni Cianchetta ,  Charles Kung ,  Tao Liu ,  Anil Kumar Padyana ,  Zhihua Sui ,  Zhenwei Cai ,  Dawei Cui ,  Jingjing Ji

IPC分类号： A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  C07D241/36 ,  C07D513/14 ,  A61K45/06

摘要： Described herein are methods of using compounds of Formula (I) to modulate PKM2 activity in a subject. These compounds are represented by Formula (I): wherein R1, R2, L1, and L2 are as defined herein.

公开(公告)号：US20200207785A1

公开(公告)日：2020-07-02

申请号：US16639081

申请日：2018-08-15

申请人： Agios Pharmaceuticals, Inc.

发明人： Giovanni Cianchetta ,  Tao Liu ,  Anil Kumar Padyana ,  Zhihua Sui ,  Zhenwei Cai ,  Dawei Cui ,  Jingjing Ji

IPC分类号： C07D513/14 ,  C07D241/36

摘要： Described herein are compounds that activate pyruvate kinase, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I) wherein R1, R2, Ra, Rb, Rj, Rk, and Q are as defined herein

公开(公告)号：US11872225B2

公开(公告)日：2024-01-16

申请号：US17586777

申请日：2022-01-27

申请人： Agios Pharmaceuticals, Inc.

发明人： Giovanni Cianchetta ,  Charles Kung ,  Tao Liu ,  Anil Kumar Padyana ,  Zhihua Sui ,  Zhenwei Cai ,  Dawei Cui ,  Jingjing Ji

IPC分类号： C07D513/14 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  C07D241/36 ,  A61K45/06

CPC分类号： A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  C07D241/36 ,  C07D513/14 ,  A61K45/06

摘要： Described herein are methods of using compounds of Formula (I) to modulate PKM2 activity in a subject. These compounds are represented by Formula (I):




wherein R1, R2, L1, and L2 are as defined herein.

公开(公告)号：US11040036B2

公开(公告)日：2021-06-22

申请号：US16952257

申请日：2020-11-19

申请人： Agios Pharmaceuticals, Inc.

发明人： Giovanni Cianchetta ,  Tao Liu ,  Anil Kumar Padyana ,  Zhihua Sui ,  Zhenwei Cai ,  Dawei Cui ,  Jingjing Ji

IPC分类号： A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  A61K45/06 ,  C07D241/36 ,  C07D513/14

摘要： Described herein are compounds that activate pyruvate kinase, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I) wherein R1, R2, Ra, Rb, Rj, Rk, and Q are as defined herein.

公开(公告)号：US20200206225A1

公开(公告)日：2020-07-02

申请号：US16639086

申请日：2018-08-15

申请人： Agios Pharmaceuticals, Inc.

发明人： Giovanni Cianchetta ,  Charles Kung ,  Tao Liu ,  Anil Kumar Padyana ,  Zhihua Sui ,  Zhenwei Cai ,  Dawei Cui ,  Jingjing Ji

IPC分类号： A61K31/5025 ,  A61K31/519 ,  A61K31/506

摘要： Described herein are methods of using compounds of Formula (I) to modulate PKM2 activity in a subject. These compounds are represented by Formula (I): wherein R1, R2, L1, and L2 are as defined herein.

公开(公告)号：US11957680B2

公开(公告)日：2024-04-16

申请号：US17744806

申请日：2022-05-16

申请人： Agios Pharmaceuticals, Inc.

发明人： Giovanni Cianchetta ,  Tao Liu ,  Anil Kumar Padyana ,  Zhihua Sui ,  Zhenwei Cai ,  Dawei Cui ,  Jingjing Ji

IPC分类号： A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  C07D241/36 ,  C07D513/14 ,  A61K45/06

CPC分类号： A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  C07D241/36 ,  C07D513/14 ,  A61K45/06

摘要： Described herein are compounds that activate pyruvate kinase R, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I): wherein R1, R2, L1, and L2 are as defined herein.

公开(公告)号：US20230226055A1

公开(公告)日：2023-07-20

申请号：US18099311

申请日：2023-01-20

申请人： Agios Pharmaceuticals, Inc.

发明人： Giovanni Cianchetta ,  Tao Liu ,  Anil Kumar Padyana ,  Zhihua Sui ,  Zhenwei Cai ,  Dawei Cui ,  Jingjing Ji

IPC分类号： A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  C07D241/36 ,  C07D513/14

CPC分类号： A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  C07D241/36 ,  C07D513/14 ,  A61K45/06

摘要： Described herein are compounds that activate pyruvate kinase, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I) wherein R1, R2, Ra, Rb, Rj, Rk, and Q are as defined herein.

公开(公告)号：US11364240B2

公开(公告)日：2022-06-21

申请号：US16639075

申请日：2018-08-15

申请人： Agios Pharmaceuticals, Inc.

发明人： Giovanni Cianchetta ,  Tao Liu ,  Anil Kumar Padyana ,  Zhihua Sui ,  Zhenwei Cai ,  Dawei Cui ,  Jingjing Ji

IPC分类号： A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  C07D241/36 ,  C07D513/14 ,  A61K45/06

摘要： Described herein are compounds that activate pyruvate kinase R, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I): wherein R1, R2, L1, and L2 are as defined herein.

公开(公告)号：US20220127267A1

公开(公告)日：2022-04-28

申请号：US17429073

申请日：2020-02-12

申请人： Agios Pharmaceuticals, Inc.

发明人： Tao Liu ,  Zhihua Sui ,  Jingjing Ji

IPC分类号： C07D471/14 ,  C07D471/04 ,  C07D513/14 ,  C07D498/14 ,  C07D495/04 ,  C07D495/14

摘要： Described herein are compounds that regulate pyruvate kinase activity, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I) wherein R2, L1-L2, U1-U7, m, ring A, and Q are as defined herein.

公开(公告)号：US20210130371A1

公开(公告)日：2021-05-06

申请号：US16639075

申请日：2018-08-15

申请人： Agios Pharmaceuticals, Inc.

发明人： Giovanni Cianchetta ,  Tao Liu ,  Anil Kumar Padyana ,  Zhihua Sui ,  Zhenwei Cai ,  Dawei Cui ,  Jingjing Ji

IPC分类号： C07D513/14 ,  A61K31/5025 ,  A61K45/06

摘要： Described herein are compounds that activate pyruvate kinase R, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I): wherein R1, R2, L1, and L2 are as defined herein.