公开(公告)号：US11634490B2

公开(公告)日：2023-04-25

申请号：US17058076

申请日：2019-06-14

Applicant: Accurus Biosciences, Inc.

Inventor： Haishan Lin ,  Yi Zhang

IPC: A61K39/00 ,  A61K39/395 ,  G01N33/53 ,  C12N5/02 ,  C12N5/20 ,  C07K16/00 ,  C07K16/46 ,  C07K16/28

Abstract: Provided are anti-CD47 antibodies or fragments thereof that can bind to the extra cellular domain of the CD47 protein. The antibodies or fragments thereof can effectively block the interaction between human CD47 and its ligand SIRP alpha and enhance the phagocytosis activity of macrophages to engulf cancer cells. Some of these antibodies or fragments do not induce in vitro hemagglutination and therefore can be suitably used as therapeutic agents with reduced off-target effects.

公开(公告)号：US20210206850A1

公开(公告)日：2021-07-08

申请号：US17058076

申请日：2019-06-14

Applicant: Accurus Biosciences, Inc.

Inventor： Haishan Lin ,  Yi Zhang

IPC: C07K16/28

Abstract: Provided are anti-CD47 antibodies or fragments thereof that can bind to the extra cellular domain of the CD47 protein. The antibodies or fragments thereof can effectively block the interaction between human CD47 and its ligand SIRP alpha and enhance the phagocytosis activity of macrophages to engulf cancer cells. Some of these antibodies or fragments do not induce in vitro hemagglutination and therefore can be suitably used as therapeutic agents with reduced off-target effects.