公开(公告)号：US20180201672A1

公开(公告)日：2018-07-19

申请号：US15322788

申请日：2015-06-30

申请人： Wen-Hwa Lee ,  Academia Sinica

发明人： Wen-Hwa Lee ,  Jin-Yuh Shew ,  Che Ma ,  Chia-Lin Chen ,  Wen-Hsin Lee ,  Chun-Kai Huang ,  Heng-Hsiung Wu

IPC分类号： C07K16/24 ,  A61P35/00 ,  C12N15/113 ,  A61K39/395 ,  A61K45/06 ,  C07K14/715

摘要： Methods and compositions for treatment and therapy of cancer are provided. Specifically, antagonists specific for interleukin-17 receptor B (IL-17RB) and its ligand IL-17B are provided. Potent neutralizing antibodies specific for IL-17RB and methods for their manufacture and use are disclosed. The invention also relates to antisense, RNAi and shRNA compositions for the prevention and treatment of cancer, in particular breast cancer and pancreatic cancer.

公开(公告)号：US10793628B2

公开(公告)日：2020-10-06

申请号：US15322788

申请日：2015-06-30

申请人： Academia Sinica

发明人： Wen-Hwa Lee ,  Jin-Yuh Shew ,  Che Ma ,  Chia-Lin Chen ,  Wen-Hsin Lee ,  Chun-Kai Huang ,  Heng-Hsiung Wu

IPC分类号： A61K39/395 ,  C07K16/24 ,  A61K45/06 ,  A61K31/713 ,  A61K38/20 ,  C07K16/28 ,  C07K16/30 ,  A61P35/00 ,  C07K14/715 ,  C12N15/113 ,  A61K39/00

摘要： Methods and compositions for treatment and therapy of cancer are provided. Specifically, antagonists specific for interleukin-17 receptor B (IL-17RB) and its ligand IL-17B are provided. Potent neutralizing antibodies specific for IL-17RB and methods for their manufacture and use are disclosed. The invention also relates to antisense, RNAi and shRNA compositions for the prevention and treatment of cancer, in particular breast cancer and pancreatic cancer.