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公开(公告)号：US20170057966A1
公开(公告)日：2017-03-02
申请号：US15248994
申请日：2016-08-26
发明人： Udo Lange , Michael Ochse , Elizabeth van der Kam , Jeroen van Bergeijk , Sean Turner , Frank Oellien , Patrick Walleser , Wilhelm Amberg , Wilfried Hornberger , Herve Geneste , Mario Mezler , Charles Hutchins
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention relates to heterocyclic compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.
摘要翻译： 本发明涉及作为S1P调节剂的杂环化合物，包含这些化合物的药物组合物及其用于治疗，缓解或预防由S1P受体介导的疾病或病症的用途。
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公开(公告)号：US10556907B2
公开(公告)日：2020-02-11
申请号：US15248994
申请日：2016-08-26
发明人： Udo Lange , Michael Ochse , Elizabeth van der Kam , Jeroen van Bergeijk , Sean Turner , Frank Oellien , Patrick Walleser , Wilhelm Amberg , Wilfried Hornberger , Herve Geneste , Mario Mezler , Charles Hutchins
IPC分类号： C07D487/04 , C07D471/04
摘要： The invention relates to heterocyclic compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.
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3.发明申请公开(公告)号：US20200039930A1
公开(公告)日：2020-02-06
申请号：US16496256
申请日：2018-03-20
发明人： Gisela Backfisch , Margaretha Henrica Maria Bakker , Lawrence Black , Wilfried Braje , Karla Drescher , Thomas Erhard , Andreas Haupt , Carolin Hoft , Andreas Kling , Viktor Lakics , Helmut Mack , Frank Oellien , Ana Lucia Relo
IPC分类号： C07D207/16
摘要： The present invention relates to proline amide compounds and their azetidine derivatives of formula I wherein the variables are as defined in the claims and the description. The invention further relates to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, to a method for preventing or treating conditions and disorders which respond to the modulation of the 5-HT2C receptor, and processes for preparing such compounds and compositions.
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公开(公告)号：US20200002354A1
公开(公告)日：2020-01-02
申请号：US16559262
申请日：2019-09-03
发明人： Gisela Backfisch , Margaretha Henrica Maria Bakker , Günter Blaich , Wilfried Braje , Karla Drescher , Thomas Erhard , Andreas Haupt , Carolin Hoft , Viktor Lakics , Helmut Mack , Frank Oellien , Raimund Peter , Ana Lucia Relo
IPC分类号： C07D498/04 , C07D498/14
摘要： The present invention relates to compound of formula (I) wherein the variables are as defined in the claims and the description. The invention further relates to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, to their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to methods for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.
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公开(公告)号：US20170174672A1
公开(公告)日：2017-06-22
申请号：US15388516
申请日：2016-12-22
发明人： Wilhelm Amberg , Udo Lange , Herve Geneste , Michael Ochse , Ralf Biesinger , Frank Oellien
IPC分类号： C07D413/12 , C07D205/04 , C07C229/48 , C07C229/46 , C07D211/62 , C07D261/12 , C07D209/52 , C07D207/16 , C07D207/08 , C07D265/36 , C07C59/72 , C07D405/04 , C07D311/04
CPC分类号： C07D413/12 , C07C59/72 , C07C229/30 , C07C229/36 , C07C229/46 , C07C229/48 , C07C229/50 , C07C2601/04 , C07C2601/14 , C07C2602/10 , C07C2602/38 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/16 , C07D209/52 , C07D209/94 , C07D211/32 , C07D211/62 , C07D261/12 , C07D265/36 , C07D265/38 , C07D311/04 , C07D311/58 , C07D405/04 , C07D405/14
摘要： The invention relates to (hetero)cyclic compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.
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公开(公告)号：US10280159B2
公开(公告)日：2019-05-07
申请号：US15388516
申请日：2016-12-22
发明人： Wilhelm Amberg , Udo Lange , Herve Geneste , Michael Ochse , Ralf Biesinger , Frank Oellien
IPC分类号： C07D413/12 , C07D205/04 , C07C229/48 , C07C229/46 , C07D211/62 , C07D261/12 , C07D209/52 , C07D207/16 , C07D207/08 , C07D265/36 , C07C59/72 , C07D405/04 , C07D311/04 , C07D405/14 , C07D311/58 , C07C229/30 , C07C229/36 , C07C229/50 , C07D207/06 , C07D265/38 , C07D209/94 , C07D211/32
摘要： The invention relates to (hetero)cyclic compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.
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