公开(公告)号：US20230312595A1

公开(公告)日：2023-10-05

申请号：US18328350

申请日：2023-06-02

申请人： AbbVie Inc.

发明人： Ayman Allian ,  Jayanthy Jayanth ,  Mohamed-Eslam F. Mohamed ,  Mathew M. Mulhern ,  Fredrik Lars Nordstrom ,  Ahmed A. Othman ,  Michael J. Rozema ,  Lakshmi Bhagavatula ,  Patrick J. Marroum ,  Peter T. Mayer ,  Ahmad Y. Sheikh ,  Thomas B. Borchardt ,  Ben Klünder

IPC分类号： C07D487/14 ,  A61K47/12 ,  A61K47/38 ,  A61K9/00 ,  A61K31/4985

CPC分类号： C07D487/14 ,  A61K47/12 ,  A61K47/38 ,  A61K9/0053 ,  A61K31/4985 ,  C07B2200/13

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20230058001A1

公开(公告)日：2023-02-23

申请号：US17951334

申请日：2022-09-23

申请人： AbbVie Inc.

发明人： Ayman Allian ,  Jayanthy Jayanth ,  Mohamed-Eslam F. Mohamed ,  Mathew M. Mulhern ,  Fredrik Lars Nordstrom ,  Ahmed A. Othman ,  Michael J. Rozema ,  Lakshmi Bhagavatula ,  Patrick J. Marroum ,  Peter T. Mayer ,  Ahmad Y. Sheikh ,  Thomas B. Borchardt ,  Ben Klünder

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20230057084A1

公开(公告)日：2023-02-23

申请号：US17951332

申请日：2022-09-23

申请人： AbbVie Inc.

发明人： Ayman Allian ,  Jayanthy Jayanth ,  Mohamed-Eslam F. Mohamed ,  Mathew M. Mulhern ,  Fredrik Lars Nordstrom ,  Ahmed A. Othman ,  Michael J. Rozema ,  Lakshmi Bhagavatula ,  Patrick J. Marroum ,  Peter T. Mayer ,  Ahmad Y. Sheikh ,  Thomas B. Borchardt ,  Ben Klünder

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US12110298B2

公开(公告)日：2024-10-08

申请号：US18369272

申请日：2023-09-18

申请人： AbbVie Inc.

发明人： Mathew M. Mulhern ,  Fredrik Lars Nordstrom ,  Ahmad Y. Sheikh

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/02 ,  A61K47/12 ,  A61K47/38 ,  C07D487/04

CPC分类号： C07D487/14 ,  A61K9/0053 ,  A61K31/4985 ,  A61K47/02 ,  A61K47/12 ,  A61K47/38 ,  C07D487/04 ,  C07B2200/13

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20240034740A1

公开(公告)日：2024-02-01

申请号：US18328325

申请日：2023-06-02

申请人： AbbVie Inc.

发明人： Ayman Allian ,  Jayanthy Jayanth ,  Mohamed-Eslam F. Mohamed ,  Mathew M. Mulhern ,  Fredrik Lars Nordstrom ,  Ahmed A. Othman ,  Michael J. Rozema ,  Lakshmi Bhagavatula ,  Patrick J. Marroum ,  Peter T. Mayer ,  Ahmad Y. Sheikh ,  Thomas B. Borchardt ,  Ben Klünder

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

CPC分类号： C07D487/14 ,  A61K9/0053 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07B2200/13

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20230322794A1

公开(公告)日：2023-10-12

申请号：US18329988

申请日：2023-06-06

申请人： AbbVie Inc.

发明人： Ayman Allian ,  Jayanthy Jayanth ,  Mohamed-Eslam F. Mohamed ,  Mathew M. Mulhern ,  Fredrik Lars Nordstrom ,  Ahmed A. Othman ,  Michael J. Rozema ,  Lakshmi Bhagavatula ,  Patrick J. Marroum ,  Peter T. Mayer ,  Ahmad Y. Sheikh ,  Thomas B. Borchardt ,  Ben Klünder

IPC分类号： C07D487/14 ,  A61K47/38 ,  A61K9/00 ,  A61K47/12 ,  A61K31/4985

CPC分类号： C07D487/14 ,  A61K47/38 ,  A61K9/0053 ,  A61K47/12 ,  A61K31/4985 ,  C07B2200/13

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20230312593A1

公开(公告)日：2023-10-05

申请号：US18174738

申请日：2023-02-27

申请人： AbbVie Inc.

发明人： Ayman Allian ,  Jayanthy Jayanth ,  Mohamed-Eslam F. Mohamed ,  Mathew M. Mulhern ,  Fredrik Lars Nordstrom ,  Ahmed A. Othman ,  Michael J. Rozema ,  Lakshmi Bhagavatula ,  Patrick J. Marroum ,  Peter T. Mayer ,  Ahmad Y. Sheikh ,  Thomas B. Borchardt ,  Ben Klünder

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

CPC分类号： C07D487/14 ,  A61K9/0053 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07B2200/13

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20240174682A1

公开(公告)日：2024-05-30

申请号：US18530077

申请日：2023-12-05

申请人： AbbVie Inc.

发明人： Ayman Allian ,  Jayanthy Jayanth ,  Mohamed-Eslam F. Mohamed ,  Mathew M. Mulhern ,  Fredrik Lars Nordstrom ,  Ahmed A. Othman ,  Michael J. Rozema ,  Lakshmi Bhagavatula ,  Patrick J. Marroum ,  Peter T. Mayer ,  Ahmad Y. Sheikh ,  Thomas B. Borchardt ,  Ben Klünder ,  Heidi S. Camp ,  Robert J. Padley ,  Jeffrey W. Voss

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/02 ,  A61K47/12 ,  A61K47/38 ,  C07D487/04

CPC分类号： C07D487/14 ,  A61K9/0053 ,  A61K31/4985 ,  A61K47/02 ,  A61K47/12 ,  A61K47/38 ,  C07D487/04 ,  C07B2200/13

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20230303582A1

公开(公告)日：2023-09-28

申请号：US18174736

申请日：2023-02-27

申请人： AbbVie Inc.

发明人： Ayman Allian ,  Jayanthy Jayanth ,  Mohamed-Eslam F. Mohamed ,  Mathew M. Mulhern ,  Fredrik Lars Nordstrom ,  Ahmed A. Othman ,  Michael J. Rozema ,  Lakshmi Bhagavatula ,  Patrick J. Marroum ,  Peter T. Mayer ,  Ahmad Y. Sheikh ,  Thomas B. Borchardt ,  Ben Klünder

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

CPC分类号： C07D487/14 ,  A61K9/0053 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07B2200/13

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US09199992B2

公开(公告)日：2015-12-01

申请号：US14644970

申请日：2015-03-11

申请人： AbbVie Inc.

发明人： Vincent S. Chan ,  Alan C. Christesen ,  Timothy A. Grieme ,  Yi-Yin Ku ,  Mathew M. Mulhern ,  Yu-Ming M. Pu

IPC分类号： C07D471/04 ,  C07C67/10 ,  C07C67/00 ,  C07C69/78

CPC分类号： C07D471/04 ,  C07C67/00 ,  C07C67/10 ,  C07C69/78 ,  C07C69/76

摘要： Provided herein is a process for the preparation of an apoptosis-inducing agent, and chemical intermediates thereof. Also provided herein are novel chemical intermediates related to the process provided herein.