-
公开(公告)号：US10556907B2
公开(公告)日：2020-02-11
申请号：US15248994
申请日：2016-08-26
发明人： Udo Lange , Michael Ochse , Elizabeth van der Kam , Jeroen van Bergeijk , Sean Turner , Frank Oellien , Patrick Walleser , Wilhelm Amberg , Wilfried Hornberger , Herve Geneste , Mario Mezler , Charles Hutchins
IPC分类号： C07D487/04 , C07D471/04
摘要： The invention relates to heterocyclic compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.
-
公开(公告)号：US20170057966A1
公开(公告)日：2017-03-02
申请号：US15248994
申请日：2016-08-26
发明人： Udo Lange , Michael Ochse , Elizabeth van der Kam , Jeroen van Bergeijk , Sean Turner , Frank Oellien , Patrick Walleser , Wilhelm Amberg , Wilfried Hornberger , Herve Geneste , Mario Mezler , Charles Hutchins
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention relates to heterocyclic compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.
摘要翻译： 本发明涉及作为S1P调节剂的杂环化合物，包含这些化合物的药物组合物及其用于治疗，缓解或预防由S1P受体介导的疾病或病症的用途。
-
3.发明申请4,5- DIHYDROPYRAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 有权4,5-二氢吡唑衍生物，含有它们的药物组合物及其在治疗中的使用公开(公告)号：US20160075691A1
公开(公告)日：2016-03-17
申请号：US14849470
申请日：2015-09-09
发明人： Wilhelm Amberg , Jason Brewer , Charles Hutchins , Udo Lange , Yanbin Lao , Huan-Qiu Li , Frauke Pohlki , Anil Vasudevan , Ying Wang , Hongyu Zhao
IPC分类号： C07D403/12 , C07D401/14
CPC分类号： C07D403/12 , C07D401/14
摘要： The present invention relates to 4,5-dihydropyrazole derivatives of the formula (I) and physiologically tolerated salts thereof which are GlyT1 inhibitors. The invention further relates to pharmaceutical compositions comprising such 4,5-dihydropyrazole derivatives, and the use of such 4,5-dihydropyrazole derivatives for therapeutic purposes.
摘要翻译： 本发明涉及式（I）的4,5-二氢吡唑衍生物及其生理学上耐受的盐，它们是GlyT1抑制剂。 本发明还涉及包含这种4,5-二氢吡唑衍生物的药物组合物，以及这些用于治疗目的的这种4,5-二氢吡唑衍生物的用途。
-
4.发明申请公开(公告)号：US20170172993A1
公开(公告)日：2017-06-22
申请号：US15449615
申请日：2017-03-03
发明人： Wilhelm Amberg , Frauke Pohlki , Udo Lange , Ying Wang , Jason Brewer , Anil Vasudevan , Yanbin Lao , Charles Hutchins , Hongyu Zhao , Huan-Qiu Li
IPC分类号： A61K31/454 , A61K31/4192 , A61K31/4025 , A61K31/4178 , A61K31/397
摘要： The present invention relates to aminotetraline and aminoindane derivatives of the formula (I) or a physiologically tolerated salt thereof.The invention relates to pharmaceutical compositions comprising such aminotetraline and aminoindane derivatives, and the use of such aminotetraline and aminoindane derivatives for therapeutic purposes. The aminotetraline and aminoindane derivatives are GlyT1 inhibitors.
-
5.发明申请Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy 有权氨基四氢化萘和氨基茚满衍生物，含有它们的药物组合物及其在治疗中的应用公开(公告)号：US20150111875A1
公开(公告)日：2015-04-23
申请号：US14517205
申请日：2014-10-17
发明人： Wilhelm Amberg , Frauke Pohlki , Udo Lange , Ying Wang , Jason Brewer , Anil Vasudevan , Yanbin Lao , Charles Hutchins , Hongyu Zhao , Huan-Qiu Li
IPC分类号： C07D403/14 , C07D405/14 , C07D403/10
CPC分类号： A61K31/454 , A61K31/397 , A61K31/4025 , A61K31/4178 , A61K31/4192 , C07D205/04 , C07D207/273 , C07D233/42 , C07D401/12 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14
摘要： The present invention relates to aminotetraline and aminoindane derivatives of the formula (I) or a physiologically tolerated salt thereof.The invention relates to pharmaceutical compositions comprising such aminotetraline and aminoindane derivatives, and the use of such aminotetraline and aminoindane derivatives for therapeutic purposes. The aminotetraline and aminoindane derivatives are GlyT1 inhibitors.
摘要翻译： 本发明涉及式（I）的氨基四氢化萘和氨基茚满衍生物或其生理上耐受的盐。 本发明涉及包含这种氨基四氢化萘和氨基茚满衍生物的药物组合物，以及这种氨基四氢化萘和氨基茚满衍生物用于治疗目的的用途。 氨基四氢化萘和氨基茚满衍生物是GlyT1抑制剂。
-
6.发明申请公开(公告)号：US20190290632A1
公开(公告)日：2019-09-26
申请号：US16276144
申请日：2019-02-14
发明人： Wilhelm Amberg , Frauke Pohlki , Udo Lange , Ying Wang , Jason Brewer , Anil Vasudevan , Yanbin Lao , Charles Hutchins , Hongyu Zhao , Huan-Qiu Li
IPC分类号： A61K31/454 , C07D405/14 , C07D403/10 , A61K31/4192 , A61K31/4178 , A61K31/4025 , C07D403/12 , C07D403/14 , C07D207/273 , C07D205/04 , C07D401/12 , C07D233/42 , A61K31/397
摘要： The present invention relates to aminotetraline and aminoindane derivatives of the formula (I) or a physiologically tolerated salt thereof.The invention relates to pharmaceutical compositions comprising such aminotetraline and aminoindane derivatives, and the use of such aminotetraline and aminoindane derivatives for therapeutic purposes. The aminotetraline and aminoindane derivatives are GlyT1 inhibitors.
-
公开(公告)号：US20170173009A1
公开(公告)日：2017-06-22
申请号：US15449565
申请日：2017-03-03
发明人： Wilhelm Amberg , Frauke Pohlki , Udo Lange , Ying Wang , Jason Brewer , Anil Vasudevan , Yanbin Lao , Charles Hutchins , Hongyu Zhao , Huan-Qiu Li
IPC分类号： A61K31/501 , A61K31/4433 , A61K31/4155 , A61K31/4192 , A61K31/4178 , A61K31/397
摘要： The present invention relates to aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives of the formula (I) or a physiologically tolerated salt thereof.The invention relates to pharmaceutical compositions comprising such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, and the use of such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquin oline derivatives for therapeutic purposes. The aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives are GlyT1 inhibitors.
-
8.发明授权4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy 有权4,5-二氢吡唑衍生物，含有它们的药物组合物及其在治疗中的用途公开(公告)号：US09550754B2
公开(公告)日：2017-01-24
申请号：US14849470
申请日：2015-09-09
发明人： Wilhelm Amberg , Jason Brewer , Charles Hutchins , Udo Lange , Yanbin Lao , Huan-Qiu Li , Frauke Pohlki , Anil Vasudevan , Ying Wang , Hongyu Zhao
IPC分类号： C07D403/12 , C07D401/14
CPC分类号： C07D403/12 , C07D401/14
摘要： The present invention relates to 4,5-dihydropyrazole derivatives of the formula (I) and physiologically tolerated salts thereof which are GlyT1 inhibitors. The invention further relates to pharmaceutical compositions comprising such 4,5-dihydropyrazole derivatives, and the use of such 4,5-dihydropyrazole derivatives for therapeutic purposes.
摘要翻译： 本发明涉及式（I）的4,5-二氢吡唑衍生物及其生理学上耐受的盐，它们是GlyT1抑制剂。 本发明还涉及包含这种4,5-二氢吡唑衍生物的药物组合物，以及这些用于治疗目的的这种4,5-二氢吡唑衍生物的用途。
-
9.发明申请Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy 有权氨基荧光素，氨基硫辛烷和氨基-1,2,3,4-四氢喹啉衍生物，含有它们的药物组合物及其在治疗中的用途公开(公告)号：US20150111867A1
公开(公告)日：2015-04-23
申请号：US14517034
申请日：2014-10-17
发明人： Wilhelm Amberg , Frauke Pohlki , Udo Lange , Ying Wang , Jason Brewer , Anil Vasudevan , Yanbin Lao , Charles Hutchins , Hongyu Zhao , Huan-Qiu Li
IPC分类号： C07D405/14 , C07D405/04
CPC分类号： A61K31/501 , A61K31/397 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/4433 , C07D311/58 , C07D405/04 , C07D405/14
摘要： The present invention relates to aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives of the formula (I) or a physiologically tolerated salt thereofThe invention relates to pharmaceutical compositions comprising such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, and the use of such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquin oline derivatives for therapeutic purposes. The aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives are GlyT1 inhibitors.
摘要翻译： 本发明涉及式（I）的氨基苯并二氢吡喃，氨基硫色烷和氨基-1,2,3,4-四氢喹啉衍生物或其生理上可耐受的盐。本发明涉及包含这种氨基苯并二氢吡喃，氨基硫色烷和氨基-1,2 ，3,4-四氢喹啉衍生物，以及用于治疗目的的这种氨基苯并二氢吡喃，氨基硫辛烷和氨基-1,2,3,4-四氢喹啉衍生物的用途。 氨基苯并二氢吡喃，氨基硫色烷和氨基-1,2,3,4-四氢喹啉衍生物是GlyT1抑制剂。
-
公开(公告)号：US20190290645A1
公开(公告)日：2019-09-26
申请号：US16275938
申请日：2019-02-14
发明人： Wilhelm Amberg , Frauke Pohlki , Udo Lange , Ying Wang , Jason Brewer , Anil Vasudevan , Yanbin Lao , Charles Hutchins , Hongyu Zhao , Huan-Qiu Li
IPC分类号： A61K31/501 , A61K31/4433 , A61K31/4192 , A61K31/4178 , C07D405/04 , A61K31/397 , C07D311/58 , C07D405/14 , A61K31/4155
摘要： The present invention relates to aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives of the formula (I) or a physiologically tolerated salt thereof.The invention relates to pharmaceutical compositions comprising such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, and the use of such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives for therapeutic purposes. The aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives are GlyT1 inhibitors.
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.032 秒)
