公开(公告)号：US09309279B2

公开(公告)日：2016-04-12

申请号：US14170199

申请日：2014-01-31

申请人： AbbVie, Inc. ,  Enanta Pharmaceuticals, Inc.

发明人： Yiyin Ku ,  Keith F. McDaniel ,  Hui-Ju Chen ,  Jason P. Shanley ,  Dale J. Kempf ,  David J. Grampovnik ,  Ying Sun ,  Dong Liu ,  Yonghua Gai ,  Yat Sun Or ,  Seble H. Wagaw ,  Kenneth Engstrom ,  Tim Grieme ,  Ahmad Sheikh ,  Jianzhang Mei

IPC分类号： C07K1/113 ,  C07D487/04

CPC分类号： C07K1/113 ,  C07D487/04

摘要： The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.

公开(公告)号：US20140148573A1

公开(公告)日：2014-05-29

申请号：US14170199

申请日：2014-01-31

申请人： Enanta Pharmaceuticals, Inc. ,  AbbVie, Inc.

发明人： Yiyin Ku ,  Keith F. McDaniel ,  Hui-Ju Chen ,  Jason P. Shanley ,  Dale J. Kempf ,  David J. Grampovnik ,  Ying Sun ,  Dong Liu ,  Yonghua Gai ,  Yat Sun Or ,  Seble H. Wagaw ,  Kenneth Engstrom ,  Tim Grieme ,  Ahmad Sheikh ,  Jianzhang Mei

IPC分类号： C07K1/113

CPC分类号： C07K1/113 ,  C07D487/04

摘要： The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.