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1.发明申请公开(公告)号：US20090024005A1
公开(公告)日：2009-01-22
申请号：US11780411
申请日：2007-07-19
CPC分类号： A61B5/1112 , A61B5/1116 , A61B5/686
摘要： An example method includes monitoring a first posture including a first lateral decubitus posture (LDP), recording a first LDP record based on the first LDP, computing a first posture trend based on the first LDP record and determining and providing a wellness indication based on the first posture trend.
摘要翻译： 一种示例性方法包括监视包括第一侧卧位姿势（LDP）的第一姿势，基于第一LDP记录第一LDP记录，基于第一LDP记录计算第一姿态趋势，并基于该第一LDP记录确定并提供健康指示 第一姿势趋势。
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2.发明授权公开(公告)号：US08801636B2
公开(公告)日：2014-08-12
申请号：US11780411
申请日：2007-07-19
CPC分类号： A61B5/1112 , A61B5/1116 , A61B5/686
摘要： An example method includes monitoring a first posture including a first lateral decubitus posture (LDP), recording a first LDP record based on the first LDP, computing a first posture trend based on the first LDP record and determining and providing a wellness indication based on the first posture trend.
摘要翻译： 一种示例性方法包括监视包括第一侧卧位姿势（LDP）的第一姿势，基于第一LDP记录第一LDP记录，基于第一LDP记录计算第一姿态趋势，并基于该第一LDP记录确定并提供健康指示 第一姿势趋势。
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3.发明授权Monitoring of chronobiological rhythms for disease and drug management using one or more implantable device 有权使用一个或多个可植入装置监测疾病和药物管理的计时生理节律公开(公告)号：US08401636B2
公开(公告)日：2013-03-19
申请号：US13209938
申请日：2011-08-15
申请人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
发明人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
IPC分类号： A61N1/18
CPC分类号： A61M5/1723 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61B5/7275 , A61N1/36114 , A61N1/36135 , A61N1/3621 , A61N1/365 , A61N1/36585 , G06F19/00
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.
摘要翻译： 使用至少一个可植入装置自动评价或预测受试者的健康状况。 在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。 也可以使用昼夜节律以外的其他时间生理节律。 可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。 预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。 还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。
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4.发明申请MONITORING OF CHRONOBIOLOGICAL RHYTHMS FOR DISEASE AND DRUG MANAGEMENT USING ONE OR MORE IMPLANTABLE DEVICE 有权使用一个或多个可植入装置监测疾病和药物管理的血液生殖系统公开(公告)号：US20110301530A1
公开(公告)日：2011-12-08
申请号：US13209938
申请日：2011-08-15
申请人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
发明人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
CPC分类号： A61M5/1723 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61B5/7275 , A61N1/36114 , A61N1/36135 , A61N1/3621 , A61N1/365 , A61N1/36585 , G06F19/00
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.
摘要翻译： 使用至少一个可植入装置自动评价或预测受试者的健康状况。 在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。 也可以使用昼夜节律以外的其他时间生理节律。 可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。 预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。 还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。
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5.发明授权Monitoring projections along principal components of multiple sensors as an indicator of worsening heart failure 有权根据多个传感器的主要组件监测预测作为心力衰竭恶化的指标公开(公告)号：US08858448B2
公开(公告)日：2014-10-14
申请号：US13325120
申请日：2011-12-14
申请人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Ramesh Wariar , John D. Hatlestad , Yi Zhang
发明人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Ramesh Wariar , John D. Hatlestad , Yi Zhang
IPC分类号： A61B5/02 , A61B5/11 , A61B5/0205 , A61B5/042 , A61B5/00 , A61B7/02 , A61B5/08 , A61N1/362 , A61B7/04 , A61N1/37 , A61B5/053
CPC分类号： A61B5/042 , A61B5/0205 , A61B5/053 , A61B5/0809 , A61B5/1107 , A61B5/6869 , A61B5/7253 , A61B7/023 , A61B7/04 , A61B2562/0219 , A61N1/3627 , A61N1/37
摘要： A device can include at least a first physiologic sensor circuit configured to provide a first physiologic signal, a second physiologic sensor circuit configured to provide a second physiologic signal, and a processor circuit. The processor circuit includes a principal component analysis circuit configured to represent data determined from the at least first and second physiologic sensor circuits as at least first and second axes, respectively, in a multidimensional space, determine one or more principal components in the multidimensional space, determine a quantitative attribute of the first and the second physiologic signals using at least one of the determined principal components or a projection of the data along the at least one determined principal component, and provide an indication of heart failure status according to the quantitative attribute to at least one of a user or a process.
摘要翻译： 装置可以包括至少第一生理传感器电路，其被配置为提供第一生理信号，被配置为提供第二生理信号的第二生理传感器电路和处理器电路。 处理器电路包括主分量分析电路，其被配置为将表示从至少第一和第二生理传感器电路确定的数据分别表示为多维空间中的至少第一和第二轴，确定多维空间中的一个或多个主要分量， 使用确定的主成分中的至少一个或沿着至少一个确定的主成分的数据的投影来确定第一和第二生理信号的定量属性，并且根据定量属性提供心力衰竭状态的指示 至少一个用户或进程。
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公开(公告)号：US09066659B2
公开(公告)日：2015-06-30
申请号：US13437318
申请日：2012-04-02
IPC分类号： A61B5/0205 , A61B5/00 , A61B5/11 , G06F19/00 , A61N1/365
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/02405 , A61B5/076 , A61B5/1116 , A61B5/1118 , A61B5/4836 , A61B5/4848 , A61B5/686 , A61B5/7246 , A61B5/7275 , A61B5/742 , A61B2560/0462 , A61B2562/0219 , A61N1/36535 , G06F19/34 , G16H20/40
摘要： Patient posture information can be received, such as to indicate a change in patient posture by at least a threshold amount. A transient response signal indicative of a change in a physiological parameter can be received at multiple instances near a change in patient posture. Waveform morphology features can be extracted from a transient response signal and used to provide an indication of a cardiac status, such as a heart failure status.
摘要翻译： 可以接收患者姿势信息，例如指示患者姿势的变化至少阈值量。 可以在患者姿势变化附近的多个实例处接收表示生理参数变化的瞬时响应信号。 可以从瞬态响应信号中提取波形形态特征，并用于提供心脏状态的指示，例如心力衰竭状态。
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7.发明申请公开(公告)号：US20120157858A1
公开(公告)日：2012-06-21
申请号：US13325120
申请日：2011-12-14
申请人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Ramesh Wariar , John D. Hatlestad , Yi Zhang
发明人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Ramesh Wariar , John D. Hatlestad , Yi Zhang
IPC分类号： A61B5/0205 , A61B5/02
CPC分类号： A61B5/042 , A61B5/0205 , A61B5/053 , A61B5/0809 , A61B5/1107 , A61B5/6869 , A61B5/7253 , A61B7/023 , A61B7/04 , A61B2562/0219 , A61N1/3627 , A61N1/37
摘要： A device can include at least a first physiologic sensor circuit configured to provide a first physiologic signal, a second physiologic sensor circuit configured to provide a second physiologic signal, and a processor circuit. The processor circuit includes a principal component analysis circuit configured to represent data determined from the at least first and second physiologic sensor circuits as at least first and second axes, respectively, in a multidimensional space, determine one or more principal components in the multidimensional space, determine a quantitative attribute of the first and the second physiologic signals using at least one of the determined principal components or a projection of the data along the at least one determined principal component, and provide an indication of heart failure status according to the quantitative attribute to at least one of a user or a process.
摘要翻译： 设备可以包括至少第一生理传感器电路，其被配置为提供第一生理信号，被配置为提供第二生理信号的第二生理传感器电路和处理器电路。 处理器电路包括主分量分析电路，其被配置为将表示从至少第一和第二生理传感器电路确定的数据分别表示为多维空间中的至少第一和第二轴，确定多维空间中的一个或多个主要分量， 使用确定的主成分中的至少一个或沿着至少一个确定的主成分的数据的投影来确定第一和第二生理信号的定量属性，并且根据定量属性提供心力衰竭状态的指示 至少一个用户或进程。
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公开(公告)号：US10596381B2
公开(公告)日：2020-03-24
申请号：US13325354
申请日：2011-12-14
申请人： Viktoria A. Averina , John D. Hatlestad , Abhilash Patangay , Pramodsingh Hirasingh Thakur , Yi Zhang , Kenneth C. Beck
发明人： Viktoria A. Averina , John D. Hatlestad , Abhilash Patangay , Pramodsingh Hirasingh Thakur , Yi Zhang , Kenneth C. Beck
摘要： An implantable or other ambulatory medical apparatus comprises a posture sensing circuit, a physiologic sensing circuit that senses a time varying physiologic signal, and a processor circuit. The processor circuit includes a posture calculation circuit and a measurement circuit. The posture calculation circuit determines a posture of the subject using posture data obtained using the posture signal and determines when the posture of the subject is steady state. The measurement circuit derives a physiologic measurement using physiologic data extracted from the physiologic signal during at least one time period when posture is determined to be steady state and provides the physiologic measurement to at least one of a user and a process in association with the determined steady state posture.
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公开(公告)号：US20120259183A1
公开(公告)日：2012-10-11
申请号：US13437318
申请日：2012-04-02
IPC分类号： A61B5/0205
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/02405 , A61B5/076 , A61B5/1116 , A61B5/1118 , A61B5/4836 , A61B5/4848 , A61B5/686 , A61B5/7246 , A61B5/7275 , A61B5/742 , A61B2560/0462 , A61B2562/0219 , A61N1/36535 , G06F19/34 , G16H20/40
摘要： Patient posture information can be received, such as to indicate a change in patient posture by at least a threshold amount. A transient response signal indicative of a change in a physiological parameter can be received at multiple instances near a change in patient posture. Waveform morphology features can be extracted from a transient response signal and used to provide an indication of a cardiac status, such as a heart failure status.
摘要翻译： 可以接收患者姿势信息，例如指示患者姿势的变化至少阈值量。 可以在患者姿势变化附近的多个实例处接收表示生理参数变化的瞬时响应信号。 可以从瞬态响应信号中提取波形形态特征，并用于提供心脏状态的指示，例如心力衰竭状态。
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公开(公告)号：US20120157798A1
公开(公告)日：2012-06-21
申请号：US13325354
申请日：2011-12-14
申请人： Viktoria A. Averina , John D. Hatlestad , Abhilash Patangay , Pramodsingh Hirasingh Thakur , Yi Zhang , Kenneth C. Beck
发明人： Viktoria A. Averina , John D. Hatlestad , Abhilash Patangay , Pramodsingh Hirasingh Thakur , Yi Zhang , Kenneth C. Beck
IPC分类号： A61B5/11 , A61B5/08 , A61B5/053 , A61B5/00 , A61B5/0205
CPC分类号： A61N1/36542 , A61B5/0205 , A61B5/0538 , A61B5/0809 , A61B5/1116 , A61B5/686 , A61B5/6869 , A61B7/04
摘要： An implantable or other ambulatory medical apparatus comprises a posture sensing circuit, a physiologic sensing circuit that senses a time varying physiologic signal, and a processor circuit. The processor circuit includes a posture calculation circuit and a measurement circuit. The posture calculation circuit determines a posture of the subject using posture data obtained using the posture signal and determines when the posture of the subject is steady state. The measurement circuit derives a physiologic measurement using physiologic data extracted from the physiologic signal during at least one time period when posture is determined to be steady state and provides the physiologic measurement to at least one of a user and a process in association with the determined steady state posture.
摘要翻译： 植入式或其他动态医疗装置包括姿势感测电路，感测时变生理信号的生理感测电路和处理器电路。 处理器电路包括姿势计算电路和测量电路。 姿势计算电路使用姿势信号获得的姿势数据来确定对象的姿势，并且确定被摄体的姿势何时处于稳定状态。 测量电路使用在至少一个时间段内从生理信号中提取的生理数据进行生理测量，当姿势被确定为稳态时，并且将生理测量结果与所确定的稳定性相关联地向用户和过程中的至少一个提供生理测量 状态。
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