公开(公告)号：US09717688B2

公开(公告)日：2017-08-01

申请号：US14612739

申请日：2015-02-03

Applicant: Australian Nuclear Science & Technology Organisation

Inventor： Kim Suzanne Finnie ,  David Jacques ,  Christophe Jean Alexandre Barbe ,  Linggen Kong

IPC: A61K9/16 ,  A61K9/14 ,  A61K9/00 ,  A61K9/50 ,  A61K38/00 ,  B01J2/08 ,  B01J13/02 ,  A61K38/17 ,  A61K38/46 ,  A61K38/48 ,  A61K38/50

CPC classification number: A61K9/14 ,  A61K9/1611 ,  A61K9/1694 ,  A61K9/501 ,  A61K38/1709 ,  A61K38/465 ,  A61K38/482 ,  A61K38/4826 ,  A61K38/50 ,  B01J2/08 ,  B01J13/02 ,  C12Y304/21001 ,  C12Y304/21062 ,  C12Y305/01005 ,  A61K2300/00

Abstract: A process is provided for releasably encapsulating a biological entity. The process comprises combining a solution of a surfactant in a non-polar solvent with a precursor material and the biological entity to form an emulsion. The emulsion comprises a polar phase dispersed in a non-polar phase, wherein the polar phase comprises the biological entity. The particles comprising the biological entity are then formed from the polar phase.

公开(公告)号：US09295654B2

公开(公告)日：2016-03-29

申请号：US14477525

申请日：2014-09-04

Applicant: AUSTRALIAN NUCLEAR SCIENCE & TECHNOLOGY ORGANISATION

Inventor： Christophe Jean Alexandre Barbe ,  Linggen Kong

IPC: A61K9/14 ,  A61K9/16 ,  A61K9/50 ,  A61K9/00 ,  A61K9/51 ,  A61K47/02 ,  C01B33/142 ,  C01B33/149 ,  A61K49/00 ,  A61K51/12

CPC classification number: A61K9/5115 ,  A61K9/5192 ,  A61K47/02 ,  A61K49/0093 ,  A61K51/1244 ,  C01B33/142 ,  C01B33/149 ,  Y10T428/2991

Abstract: The invention provides a process for forming a layered nanoparticle, comprising providing a suspension comprising a core particle in a first liquid, adding a second liquid to the suspension, and adding a reagent, or a precursor for the reagent, to the suspension. The second liquid is immiscible with the first liquid. If the reagent is added to the suspension, the reagent reacts to form a layer on the core particle to form the layered nanoparticle. If a precursor for the reagent is added to the suspension, the precursor is converted to the reagent, and the reagent reacts to form a layer on the core particle to form the layered nanoparticle.

Abstract translation: 本发明提供一种形成层状纳米颗粒的方法，包括提供在第一液体中包含核心颗粒的悬浮液，向悬浮液中加入第二液体，并向试剂中加入试剂或试剂前体。 第二液体与第一液体不混溶。 如果将试剂加入到悬浮液中，则试剂在核心颗粒上反应形成层，形成层状纳米颗粒。 如果将试剂的前体加入悬浮液中，则将前体转化为试剂，并且试剂在核心颗粒上反应形成层以形成层状纳米颗粒。