公开(公告)号：US20240325407A1

公开(公告)日：2024-10-03

申请号：US18666388

申请日：2024-05-16

Applicant: ATAI Therapeutics, Inc.

Inventor： Holger WEIS ,  Emeline MAILLET

IPC: A61K31/55 ,  A61K31/135 ,  A61K31/137 ,  A61K31/4025 ,  A61K31/439 ,  A61K31/4468 ,  A61K31/4535 ,  A61K31/485 ,  A61K36/24

CPC classification number: A61K31/55 ,  A61K31/135 ,  A61K31/137 ,  A61K31/4025 ,  A61K31/439 ,  A61K31/4468 ,  A61K31/4535 ,  A61K31/485 ,  A61K36/24

Abstract: Methods and compositions for potentiating the effect of an opioid analgesic in a patient undergoing or planning to undergo opioid analgesic therapy using a potentiating amount of iboga alkaloid or pharmaceutically acceptable salt and/or solvate thereof that does not prolong the patient's QT interval by more than about 50 milliseconds.