公开(公告)号：US20240252432A1

公开(公告)日：2024-08-01

申请号：US18577176

申请日：2022-07-08

申请人： ASTRAZENECA PHARMACEUTICALS LP

发明人： Vidya JOSHI ,  James ARCHBELL ,  Kellisa LACHACZ ,  Charina LAMPA ,  Lauren MELLO ,  Gertrude GUTIERREZ ,  David LECHUGA-BALLESTEROS ,  Penny TAN ,  Michael RIEBE

IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K31/167 ,  A61K31/4015 ,  A61K31/44 ,  A61K31/58

CPC分类号： A61K9/008 ,  A61K9/1617 ,  A61K31/167 ,  A61K31/4015 ,  A61K31/44 ,  A61K31/58

摘要： Compositions, methods, and systems are provided for pulmonary delivery of active agents via a metered dose inhaler. In some embodiments, the compositions comprise an HFO-1234ze(E) suspension medium, active agent particles, and suspending particles. The active agent particles may comprise one, two, three or four active agent(s) selected from a long-acting muscarinic antagonist (LAMA), a long-acting β2-agonists (LABA), a short-acting beta-agonists (SABA), an inhaled corticosteroid (ICS), and a non-corticosteroid anti-inflammatory agent.

公开(公告)号：US20240358662A1

公开(公告)日：2024-10-31

申请号：US18577165

申请日：2022-07-08

申请人： ASTRAZENECA PHARMACEUTICALS LP

发明人： Vidya JOSHI ,  James ARCHBELL ,  Kellisa LACHACZ ,  Charina LAMPA ,  Lauren MELLO ,  Gertrude GUTIERREZ ,  David LECHUGA-BALLESTEROS ,  Penny TAN ,  Michael RIEBE

IPC分类号： A61K31/167 ,  A61K9/00 ,  A61K9/16 ,  A61K31/40 ,  A61K31/58 ,  A61K47/06 ,  A61M15/00

CPC分类号： A61K31/167 ,  A61K9/008 ,  A61K9/1617 ,  A61K31/40 ,  A61K31/58 ,  A61K47/06 ,  A61M15/0001

摘要： Compositions, methods, and systems are provided for pulmonary delivery of active agents via a metered dose inhaler. In some embodiments, the compositions comprise an HFO-1234ze (E) suspension medium, active agent particles, and suspending particles. The active agent particles may comprise one, two, three or four active agent(s) selected from a long-acting muscarinic antagonist (LAMA), a long-acting β2-agonists (LABA), a short-acting beta-agonists (SABA), an inhaled corticosteroid (ICS), and a non-corticosteroid anti-inflammatory agent.

公开(公告)号：US20240252440A1

公开(公告)日：2024-08-01

申请号：US18577168

申请日：2022-07-08

申请人： ASTRAZENECA PHARMACEUTICALS LP

发明人： Vidya JOSHI ,  James ARCHBELL ,  Kellisa LACHACZ ,  Charina LAMPA ,  Lauren MELLO ,  Gertrude GUTIERREZ ,  David LECHUGA-BALLESTEROS ,  Penny TAN ,  Michael RIEBE

IPC分类号： A61K9/16 ,  A61K9/00 ,  A61K31/136 ,  A61K31/58 ,  A61K47/06 ,  A61M15/00

CPC分类号： A61K9/1617 ,  A61K9/008 ,  A61K9/1611 ,  A61K31/136 ,  A61K31/58 ,  A61K47/06 ,  A61M15/0013

摘要： Compositions, methods, and systems are provided for pulmonary delivery of active agents via a metered dose inhaler. In some embodiments, the compositions comprise an HFO-1234ze(E) suspension medium, active agent particles, and suspending particles. The active agent particles may comprise one, two, three or four active agent(s) selected from a long-acting muscarinic antagonist (LAMA), a long-acting β2-agonists (LABA), a short-acting beta-agonists (SABA), an inhaled corticosteroid (ICS), and a non-corticosteroid anti-inflammatory agent.