公开(公告)号：US12043833B2

公开(公告)日：2024-07-23

申请号：US17854575

申请日：2022-06-30

Applicant: ARBUTUS BIOPHARMA CORPORATION

Inventor： James Heyes ,  Richard J. Holland ,  Adam Judge ,  Amy C. H. Lee ,  Alan D. Martin ,  Nicholas Michael Snead ,  Emily P. Thi ,  Mark Wood ,  Xin Ye

IPC: C12N15/113

CPC classification number: C12N15/1131 ,  C12N2310/14 ,  C12N2310/344 ,  C12N2310/346 ,  C12N2310/3515

Abstract: The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

公开(公告)号：US11427823B2

公开(公告)日：2022-08-30

申请号：US16603771

申请日：2018-04-10

Applicant: ARBUTUS BIOPHARMA CORPORATION

Inventor： James Heyes ,  Richard J. Holland ,  Adam Judge ,  Amy C. H. Lee ,  Alan D. Martin ,  Nicholas Michael Snead ,  Emily P. Thi ,  Mark Wood ,  Xin Ye

IPC: C12N15/113

Abstract: The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).