公开(公告)号：US12156900B2

公开(公告)日：2024-12-03

申请号：US16764463

申请日：2018-11-16

Applicant: Amgen Inc.

Inventor： Yael Wexler-Cohen ,  William J. Callahan ,  Robert Matthew Fesinmeyer ,  Rahul Rajan Kaushik ,  Sai Chakradhar Padala

IPC: A61K38/18 ,  A61K9/00 ,  A61K47/02 ,  A61K47/14 ,  A61K47/18 ,  A61K47/26 ,  A61K47/34

Abstract: Protein formulations and methods of making and using such formulations are provided herein. The formulation can be an ophthalmic formulation, such as for intravitreal administration. In some embodiments, the formulation comprises a VEGFR-Fc fusion protein, such as aflibercept.

公开(公告)号：US20210163531A1

公开(公告)日：2021-06-03

申请号：US17046662

申请日：2019-03-28

Applicant: AMGEN INC.

Inventor： William Callahan ,  Lorenzo Desantiago ,  Clea Talley ,  Yael Wexler-Cohen ,  Jeffrey Abel ,  Rahul Kaushik ,  Nitya Mariam Jacob ,  Carson Tran ,  Nicole Ball ,  Monica Goss

IPC: C07K1/36 ,  C07K1/34 ,  C07K1/18 ,  C07K1/16 ,  C07K16/28 ,  C07K16/30 ,  C07K14/535 ,  C07K14/505 ,  C07K14/71 ,  C07K14/715 ,  C07K16/40 ,  C07K16/32 ,  C07K16/22 ,  C07K16/18

Abstract: The invention relates to methods for preparing stable buffered and buffer-free protein compositions. The invention also relates to methods of purifying proteins from one or more impurities.