公开(公告)号：US12122841B2

公开(公告)日：2024-10-22

申请号：US17111442

申请日：2020-12-03

Applicant: AMGEN INC.

Inventor： Thomas C. Boone ,  David W. Brankow ,  Colin V. Gegg, Jr. ,  Shaw-Fen Sylvia Hu ,  Chadwick T. King ,  Hsieng Sen Lu ,  Licheng Shi ,  Cen Xu

IPC: C07K16/28 ,  A61K39/395 ,  C12N5/10 ,  C12N15/00 ,  C12N15/63 ,  A61K39/00

CPC classification number: C07K16/2869 ,  A61K39/39533 ,  A61K39/395 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/32 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  C12N5/10 ,  C12N15/00 ,  C12N15/63

Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.

公开(公告)号：US09862771B2

公开(公告)日：2018-01-09

申请号：US14752493

申请日：2015-06-26

Applicant: AMGEN INC.

Inventor： Thomas C. Boone ,  David W. Brankow ,  Colin V. Gegg, Jr. ,  Shaw-Fen Sylvia Hu ,  Chadwick T. King ,  Hsieng Sen Lu ,  Licheng Shi ,  Cen Xu

IPC: A61K39/395 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2869 ,  A61K39/395 ,  A61K39/39533 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/32 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.

公开(公告)号：US20130316448A1

公开(公告)日：2013-11-28

申请号：US13957916

申请日：2013-08-02

Applicant: AMGEN INC.

Inventor： Thomas C. Boone ,  Kenneth D. Wild ,  Karen C. Sitney ,  Ho-Sung Min ,  Bruce Kimmel

IPC: C07K16/22 ,  C07K14/00 ,  C07K7/08

CPC classification number: C07K16/22 ,  A61K38/00 ,  C07H21/04 ,  C07K7/08 ,  C07K14/001

Abstract: The present invention relates to certain biologically active peptides and polypeptides which can be used as therapeutics or prophylactics against diseases or disorders linked to NGF as the causative agent. In one aspect of the present invention, pharmacologically active polypeptides comprising peptides linked to one or more Fc domains are provided.

Abstract translation: 本发明涉及某些生物活性肽和多肽，其可以用作治疗剂或预防药物以抵抗作为致病剂与NGF相关的疾病或病症。 在本发明的一个方面，提供了包含与一个或多个Fc结构域连接的肽的药理活性多肽。

公开(公告)号：US12134652B2

公开(公告)日：2024-11-05

申请号：US17111453

申请日：2020-12-03

Applicant: AMGEN INC.

Inventor： Thomas C. Boone ,  David W. Brankow ,  Colin V. Gegg, Jr. ,  Shaw-Fen Sylvia Hu ,  Chadwick T. King ,  Hsieng Sen Lu ,  Licheng Shi ,  Cen Xu

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  G01N33/53 ,  C12N5/10 ,  C12N15/00 ,  C12N15/63

Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.