公开(公告)号：US11541103B2

公开(公告)日：2023-01-03

申请号：US16054035

申请日：2018-08-03

Applicant: AMGEN INC.

Inventor： Khaled M. K. Z. Ali ,  Neeraj Jagdish Agrawal ,  Gunasekaran Kannan ,  Ian Foltz ,  Zhulun Wang ,  Darren Bates ,  Marissa Mock ,  Shunsuke Takenaka

IPC: A61K38/20 ,  A61K47/69 ,  A61K47/68 ,  C07K14/54 ,  A61P35/00 ,  C07K16/28 ,  C12N15/63

Abstract: Provided herein are IL-21 muteins and fusion proteins comprising the same for use in methods of treating a disease. Related conjugates, nucleic acids, vectors, host cells, pharmaceutical compositions and kits are also provided herein. Methods of making the IL-21 muteins and fusion proteins comprising the same, as well as methods of treating a subject in need thereof, are provided by the present disclosure. Further provided are PD-1 antigen-binding proteins.

公开(公告)号：US11926672B2

公开(公告)日：2024-03-12

申请号：US17127629

申请日：2020-12-18

Applicant: Amgen Inc.

Inventor： Xin Yu ,  Jackson Egen ,  Fernando Garces ,  Shunsuke Takenaka ,  AeRyon Kim ,  Deepali Sawant

IPC: C07K16/28 ,  A61P35/04 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/2878 ,  A61P35/04 ,  C07K16/30 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/35 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/75 ,  C07K2317/92

Abstract: The present invention relates to a human agonistic CD40 multispecific antibody construct for treatment of solid tumors by engineering a molecule that specifically targets the CD40 pathway on tumor-associated APCs, without systemic CD40 activation.

公开(公告)号：US20190270817A1

公开(公告)日：2019-09-05

申请号：US16245733

申请日：2019-01-11

Applicant: AMGEN INC.

Inventor： Khaled M.K.Z. Ali ,  Neeraj Jagdish Agrawal ,  Gunasekaran Kannan ,  Ian Foltz ,  Zhulun Wang ,  Daren Bates ,  Marissa Mock ,  Shunsuke Takenaka

IPC: C07K16/28 ,  C07K16/06 ,  A61P35/00 ,  C12N15/85

Abstract: Provided herein are PD-1 antigen-binding proteins and related nucleic acids, vectors, host cells, kits and pharmaceutical compositions. Methods of making PD-1 antigen-binding proteins and methods of treating a subject are further provided.

公开(公告)号：US11518808B2

公开(公告)日：2022-12-06

申请号：US16245733

申请日：2019-01-11

Applicant: AMGEN INC.

Inventor： Khaled M. K. Z. Ali ,  Neeraj Jagdish Agrawal ,  Gunasekaran Kannan ,  Ian Foltz ,  Zhulun Wang ,  Daren Bates ,  Marissa Mock ,  Shunsuke Takenaka

IPC: C07K16/28 ,  A61P35/00 ,  A61K39/395 ,  C07K16/06 ,  C12N15/85

Abstract: Provided herein are PD-1 antigen-binding proteins and related nucleic acids, vectors, host cells, kits and pharmaceutical compositions. Methods of making PD-1 antigen-binding proteins and methods of treating a subject are further provided.

公开(公告)号：US20190046611A1

公开(公告)日：2019-02-14

申请号：US16054035

申请日：2018-08-03

Applicant: AMGEN INC.

Inventor： Khaled M.K.Z. Ali ,  Neeraj Jagdish Agrawal ,  Gunasekaran Kannan ,  Ian Foltz ,  Zhulun Wang ,  Darren Bates ,  Marissa Mock ,  Shunsuke Takenaka

IPC: A61K38/20 ,  A61P35/00 ,  C12N15/63 ,  C07K16/28

Abstract: Provided herein are IL-21 muteins and fusion proteins comprising the same for use in methods of treating a disease. Related conjugates, nucleic acids, vectors, host cells, pharmaceutical compositions and kits are also provided herein. Methods of making the IL-21 muteins and fusion proteins comprising the same, as well as methods of treating a subject in need thereof, are provided by the present disclosure. Further provided are PD-1 antigen-binding proteins.