公开(公告)号：US11926672B2

公开(公告)日：2024-03-12

申请号：US17127629

申请日：2020-12-18

Applicant: Amgen Inc.

Inventor： Xin Yu ,  Jackson Egen ,  Fernando Garces ,  Shunsuke Takenaka ,  AeRyon Kim ,  Deepali Sawant

IPC: C07K16/28 ,  A61P35/04 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/2878 ,  A61P35/04 ,  C07K16/30 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/35 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/75 ,  C07K2317/92

Abstract: The present invention relates to a human agonistic CD40 multispecific antibody construct for treatment of solid tumors by engineering a molecule that specifically targets the CD40 pathway on tumor-associated APCs, without systemic CD40 activation.