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公开(公告)号：US20170002079A1
公开(公告)日：2017-01-05
申请号：US15178652
申请日：2016-06-10
Applicant: Amgen Inc.
Inventor： Dirk E. SMITH , Ian FOLTZ , Chadwick T. KING , Ai Ching LIM , Rutilio CLARK , Michael R. COMEAU , Randal R. KETCHEM , Donghui SHI , Xiaoshan MIN , Zhulun WANG
IPC: C07K16/28
CPC classification number: C07K16/2866 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/11
Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
Abstract translation: 本文描述的是与抗原结合蛋白相关的组合物和方法，其结合人ST2，包括抗体。 在具体实施方案中，本公开提供完全人抗-ST2抗体及其衍生物及其变体。 还提供了编码这种抗体和抗体片段，变体和衍生物的核酸。 此外，提供制备和使用这些抗体的方法，包括治疗和预防自身免疫性和炎症性疾病的方法。
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公开(公告)号：US20130336926A1
公开(公告)日：2013-12-19
申请号：US13915263
申请日：2013-06-11
Applicant: Amgen Inc.
Inventor： John E. SIMS , Blair R. RENSHAW , Christopher GABEL , Jennifer E. TOWNE , Randal R. KETCHEM
IPC: C07K14/545 , C07K16/24
CPC classification number: C07K14/545 , A61K38/00 , A61K39/00 , C07K16/245 , C07K2317/75 , C12Q1/37 , G01N2333/545 , G01N2500/02 , G01N2500/20
Abstract: The present invention provides compositions and methods relating to IL-1Rrp2 requiring proteins.
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3.发明公开公开(公告)号：US20240010708A1
公开(公告)日：2024-01-11
申请号：US18238696
申请日：2023-08-28
Applicant: AMGEN INC.
Inventor： Jeonghoon SUN , Jason Charles O'NEILL , Randal R. KETCHEM , Randy Ira HECHT , Edward J. BELOUSKI , Mark Leo MICHAELS
IPC: C07K14/81
CPC classification number: C07K14/8146 , A61K38/00
Abstract: There are disclosed TIMP-3 muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them.
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4.发明申请公开(公告)号：US20220089689A1
公开(公告)日：2022-03-24
申请号：US17491715
申请日：2021-10-01
Applicant: AMGEN INC.
Inventor： Jason C. O'NEILL , Randal R. KETCHEM , TaeWeon LEE , Vishnu CHINTALGATTU , Jennitte LeAnn STEVENS
IPC: C07K14/81
Abstract: There are disclosed TIMP-3 muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them.
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公开(公告)号：US20170267769A1
公开(公告)日：2017-09-21
申请号：US15601868
申请日：2017-05-22
Applicant: Amgen Inc.
Inventor： Dirk E. SMITH , Ian FOLTZ , Chadwick T. KING , Ai Ching LIM , Rutilio CLARK , Michael R. COMEAU , Randal R. KETCHEM , Donghui SHI , Xiaoshan MIN , Zhulun WANG
IPC: C07K16/28
CPC classification number: C07K16/2866 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/11
Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
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Patent Agency Ranking
公开(公告)号：US20150064204A1
公开(公告)日：2015-03-05
申请号：US14472116
申请日：2014-08-28
Applicant: AMGEN INC.
Inventor： Courtney BEERS , Jason C. O'NEILL , Ian FOLTZ , Randal R. KETCHEM , Julia C. PIASECKI
IPC: C07K16/28 , A61K45/06 , A61K39/395
CPC classification number: C07K16/2878 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/71 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/94
Abstract: Antigen binding proteins that activate GITR are provided. Nucleic acids encoding the antigen binding proteins and vectors and cells containing such nucleic acids are also provided. The antigen binding proteins have value in therapeutic methods in which it is useful to to stimulate GITR signaling, thereby inducing or enhancing an immune response in a subject. Accordingly, the antigen binding proteins have utility in a varienty of immunotherapy treatments, including treatment of various cancers and infections.
Abstract translation: 提供激活GITR的抗原结合蛋白。 还提供了编码抗原结合蛋白的核酸和含有此类核酸的载体和细胞。 抗原结合蛋白在治疗方法中具有价值，其中可用于刺激GITR信号传导，从而诱导或增强受试者的免疫应答。 因此，抗原结合蛋白可用于免疫治疗治疗的变体，包括治疗各种癌症和感染。
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公开(公告)号：US20150017123A1
公开(公告)日：2015-01-15
申请号：US14493169
申请日：2014-09-22
Applicant: Amgen Inc.
Inventor： John E. SIMS , Blair R. RENSHAW , Christopher GABEL , Jennifer E. TOWNE , Randal R. KETCHEM
IPC: C07K14/545
CPC classification number: C07K14/545 , A61K38/00 , A61K39/00 , C07K16/245 , C07K2317/75 , C12Q1/37 , G01N2333/545 , G01N2500/02 , G01N2500/20
Abstract: The present invention provides compositions and methods relating to IL-1Rrp2 requiring proteins.
Abstract translation: 本发明提供了涉及需要蛋白质的IL-1Rrp2的组合物和方法。
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公开(公告)号：US20140004107A1
公开(公告)日：2014-01-02
申请号：US13897096
申请日：2013-05-17
Applicant: Amgen Inc.
Inventor： Dirk E. SMITH , Ian FOLTZ , Chadwick T. KING , Ai Ching LIM , Rutilio CLARK , Michael R. COMEAU , Randal R. KETCHEM , Donghui SHI , Xiaoshan MIN , Zhulun WANG
CPC classification number: C07K16/2866 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/11
Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
Abstract translation: 本文描述的是与抗原结合蛋白相关的组合物和方法，其结合人ST2，包括抗体。 在具体实施方案中，本公开提供完全人抗-ST2抗体及其衍生物及其变体。 还提供了编码这种抗体和抗体片段，变体和衍生物的核酸。 此外，提供制备和使用这些抗体的方法，包括治疗和预防自身免疫性和炎症性疾病的方法。
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公开(公告)号：US20240368292A1
公开(公告)日：2024-11-07
申请号：US18611364
申请日：2024-03-20
Applicant: Amgen Inc.
Inventor： Dirk E. SMITH , Ian FOLTZ , Chadwick T. KING , Ai Ching LIM , Rutilio CLARK , Michael R. COMEAU , Randal R. KETCHEM , Donghui SHI , Xiaoshan MIN , Zhulun WANG
Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
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公开(公告)号：US20220119537A1
公开(公告)日：2022-04-21
申请号：US17339301
申请日：2021-06-04
Applicant: Amgen Inc.
Inventor： Dirk E. SMITH , Ian FOLTZ , Chadwick T. KING , Ai Ching LIM , Rutilio CLARK , Michael R. COMEAU , Randal R. KETCHEM , Donghui SHI , Xiaoshan MIN , Zhulun WANG
Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
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