公开(公告)号：US20240263875A1

公开(公告)日：2024-08-08

申请号：US18564675

申请日：2022-05-24

Applicant: AMGEN INC.

Inventor： Philippe Lam ,  Gioval Scalzo ,  Nitin Rathore

IPC: F26B5/06 ,  F26B5/04

CPC classification number: F26B5/06 ,  F26B5/044

Abstract: A method of lyophilizing a target material includes placing a container with a target material in a lyophilizer of a lyophilization system. The lyophilization system includes the lyophilizer, a refrigeration system coupled to the lyophilizer, a temperature controller coupled to the refrigeration system, and a flow path connecting the lyophilizer and the refrigeration system. The method includes activating the lyophilizer where the lyophilizer includes a plurality of walls defining an interior chamber and at least one shelf disposed in the interior chamber. The method includes running a freezing cycle, running a primary drying cycle, and running a secondary drying cycle. The method includes pumping a thermal fluid through the flow path in fluid communication with the at least one shelf and at least one wall. Running the freezing cycle includes pumping the thermal fluid through the at least one wall of the plurality of walls.