公开(公告)号：US20250129160A1

公开(公告)日：2025-04-24

申请号：US18566228

申请日：2022-06-02

Applicant: AMGEN RESEARCH (MUNICH) GmbH ,  AMGEN INC.

Inventor： Johannes BROZY ,  Christoph DAHLHOFF ,  Tobias RAUM ,  Jochen S. PENDZIALEK ,  Lisa WINKEL ,  Marcus MUENZ ,  Nathan William PIERCE ,  Agnieszka KIELCZEWSKA ,  Wentao CHEN ,  Darren L. BATES ,  Claudia BLUEMEL ,  Jonas Karl-Josef HONER

IPC: C07K16/28

Abstract: The present invention provides single chain T cell engager (TCE) molecules having an scFab that binds a target antigen and an scFv that binds CD3, and TCE molecules that bind CCR8 and CD3. Methods of treating cancer are also provided.

公开(公告)号：US20220227888A1

公开(公告)日：2022-07-21

申请号：US17616575

申请日：2020-06-05

Applicant: AMGEN INC.

Inventor： Johannes BROZY ,  Pavan GHATTYVENKATAKRISHNA ,  Brendan AMER

IPC: C07K16/46 ,  C07K14/725 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  C07K14/765

Abstract: New formats of bispecific binding constructs with protease cleavable linkers are described, as well as their methods of making. Additionally, uses in therapeutic indications are also described.

公开(公告)号：US20220017636A1

公开(公告)日：2022-01-20

申请号：US17323884

申请日：2021-05-18

Applicant: Amgen Inc. ,  Amgen Research (Munich) GmbH ,  Immatics Biotechnologies GmbH

Inventor： Ian Nevin FOLTZ ,  Weihsu Claire CHEN ,  Lars GAEDTKE ,  Susmith MUKUND ,  Tobias RAUM ,  Heiko SCHUSTER ,  Kristin TARBELL ,  Derek E. PIPER ,  Johannes BROZY ,  Markus MUENZ ,  Igor D'ANGELO

IPC: C07K16/30 ,  C07K16/28 ,  A61P35/00

Abstract: The present invention relates to antibody constructs comprising a domain which binds to a MAGEB2 peptide complexed with an HLA and optionally, another domain which binds to CD3. Moreover, the invention provides polynucleotides encoding the antibody constructs, vectors comprising said polynucleotides and host cells transformed or transfected with said polynucleotides or vectors. Furthermore, the invention provides processes for producing the antibody constructs of the invention, medical uses of said antibody constructs, and kits comprising said antibody constructs.