公开(公告)号：US20220259329A1

公开(公告)日：2022-08-18

申请号：US17616580

申请日：2020-06-05

Applicant: AMGEN INC.

Inventor： Pavan GHATTYVENKATAKRISHNA ,  Brendan AMER

IPC: C07K16/46 ,  A61P35/00 ,  C07K16/30

Abstract: New formats of bispecific binding constructs are described, as well as their methods of making. Additionally, uses in therapeutic indications are also described.

公开(公告)号：US20220227888A1

公开(公告)日：2022-07-21

申请号：US17616575

申请日：2020-06-05

Applicant: AMGEN INC.

Inventor： Johannes BROZY ,  Pavan GHATTYVENKATAKRISHNA ,  Brendan AMER

IPC: C07K16/46 ,  C07K14/725 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  C07K14/765

Abstract: New formats of bispecific binding constructs with protease cleavable linkers are described, as well as their methods of making. Additionally, uses in therapeutic indications are also described.