公开(公告)号：US12059555B2

公开(公告)日：2024-08-13

申请号：US17009868

申请日：2020-09-02

Applicant: AMGEN INC.

Inventor： Wael Mismar ,  Jessica Hai Liu ,  Dylan Bourelle ,  Chia-Jung Wu ,  Shaun Devitt ,  Kenneth G. Schalhoub ,  Tej Desai ,  Mads Schjoth Due ,  Anthony Bitong ,  Arin Keshishian ,  Chelsea Balli-Cruz ,  Pierre Burquel ,  Ryan Oba ,  Malak Guirguis

IPC: A61M5/31 ,  A61M5/00 ,  A61K38/17 ,  A61K39/395 ,  A61M5/315

CPC classification number: A61M5/3137 ,  A61M5/002 ,  A61K38/179 ,  A61K39/395 ,  A61M5/001 ,  A61M2005/3139 ,  A61M5/31505

Abstract: An injection device is provided, including a syringe having a barrel and a flange and a backstop configured to be coupled with the syringe adjacent to the flange. The backstop includes an inner surface generally extending around at least a portion of the syringe, wherein the inner surface includes at least one protrusion extending away from the inner surface and configured to engage the flange and/or the barrel to permit or promote airflow through a space between the inner surface and the syringe.

公开(公告)号：US20240366877A1

公开(公告)日：2024-11-07

申请号：US18674549

申请日：2024-05-24

Applicant: AMGEN INC.

Inventor： Wael Mismar ,  Jessica Hai Liu ,  Dylan Bourelle ,  Chia-Jung Wu ,  Shaun Devitt ,  Kenneth G. Schalhoub ,  Tej Desai ,  Mads Schjoth Due ,  Anthony Bitong ,  Arin Keshishian ,  Chelsea Balli-Cruz ,  Pierre Burquel ,  Ryan Oba ,  Malak Guirguis

IPC: A61M5/31 ,  A61K38/17 ,  A61K39/395 ,  A61M5/00 ,  A61M5/315

Abstract: An injection device is provided, including a syringe having a barrel and a flange and a backstop configured to be coupled with the syringe adjacent to the flange. The backstop includes an inner surface generally extending around at least a portion of the syringe, wherein the inner surface includes at least one protrusion extending away from the inner surface and configured to engage the flange and/or the barrel to permit or promote airflow through a space between the inner surface and the syringe.

公开(公告)号：US12233177B2

公开(公告)日：2025-02-25

申请号：US17022695

申请日：2020-09-16

Applicant: AMGEN INC.

Inventor： Wael Mismar ,  Jessica Hai Liu ,  Chia-Jung Wu ,  Shermeen A. Abbas ,  Shaun Devitt ,  Kenneth G. Schalhoub ,  Anthony Bitong ,  Mads Schjoth Due ,  Malak Guirguis ,  Rami Saifan

IPC: A61L2/20 ,  A61L2/26

Abstract: A method of externally sterilizing a drug delivery device utilizing Nitrogen Dioxide (NO2) is provided, including placing the drug delivery device in a sterilization chamber, introducing into the chamber a dose of NO2 having a concentration of between about 2 and 20 milligrams per Liter by applying a vacuum level of between about 10 and 600 Torr and holding the vacuum level for a dwell time of between about 2 and 20 minutes, repeating the step of introducing into the chamber a dose of NO2 for a number of pulses between about 1 and 24, purging the sterilization chamber of at least substantially all of the NO2, and aerating the sterilization chamber.

公开(公告)号：US20210060258A1

公开(公告)日：2021-03-04

申请号：US17009868

申请日：2020-09-02

Applicant: AMGEN INC.

Inventor： Wael Mismar ,  Jessica Hai Liu ,  Dylan Bourelle ,  Chia-Jung Wu ,  Shaun Devitt ,  Kenneth G. Schalhoub ,  Tej Desai ,  Mads Schjoth Due ,  Anthony Bitong ,  Arin Keshishian ,  Chelsea Balli-Cruz ,  Pierre Burquel ,  Ryan Oba ,  Malak Guirguis

IPC: A61M5/315 ,  A61M5/00 ,  A61M5/31 ,  A61K38/17 ,  A61K39/395

Abstract: An injection device is provided, including a syringe having a barrel and a flange and a backstop configured to be coupled with the syringe adjacent to the flange. The backstop includes an inner surface generally extending around at least a portion of the syringe, wherein the inner surface includes at least one protrusion extending away from the inner surface and configured to engage the flange and/or the barrel to permit or promote airflow through a space between the inner surface and the syringe.

公开(公告)号：US20220160972A1

公开(公告)日：2022-05-26

申请号：US17440906

申请日：2020-04-22

Applicant: AMGEN INC.

Inventor： Cheng-Chieh Chou ,  Mingda Eu ,  Ren-Yo Forng ,  Malak Guirguis ,  Olivia Alice Henderson ,  Jessica Hai Liu ,  Robert W. Swift ,  Chia-Jung Wu

IPC: A61M5/50 ,  A61M5/31 ,  A61M5/32

Abstract: A syringe sterilization verification assembly includes a syringe, a tip cap assembly, and a biological indicator (BI) member. The syringe includes a barrel having a tip. The tip cap assembly includes an insert having a skirt configured to receive the tip. And the biological indicator (BI) member has an annular portion disposed around at least a portion of the tip and disposed radially between the tip and the skirt of the insert.

公开(公告)号：US20210077645A1

公开(公告)日：2021-03-18

申请号：US17022695

申请日：2020-09-16

Applicant: AMGEN INC.

Inventor： Wael Mismar ,  Jessica Hai Liu ,  Chia-Jung Wu ,  Shermeen A. Abbas ,  Shaun Devitt ,  Kenneth G. Schalhoub ,  Anthony Bitong ,  Mads Schjoth Due ,  Malak Guirguis ,  Rami Saifan

IPC: A61L2/20 ,  A61L2/26

Abstract: A method of externally sterilizing a drug delivery device utilizing Nitrogen Dioxide (NO2) is provided, including placing the drug delivery device in a sterilization chamber, introducing into the chamber a dose of NO2 having a concentration of between about 2 and 20 milligrams per Liter by applying a vacuum level of between about 10 and 600 Torr and holding the vacuum level for a dwell time of between about 2 and 20 minutes, repeating the step of introducing into the chamber a dose of NO2 for a number of pulses between about 1 and 24, purging the sterilization chamber of at least substantially all of the NO2, and aerating the sterilization chamber.