公开(公告)号：US20210077645A1

公开(公告)日：2021-03-18

申请号：US17022695

申请日：2020-09-16

Applicant: AMGEN INC.

Inventor： Wael Mismar ,  Jessica Hai Liu ,  Chia-Jung Wu ,  Shermeen A. Abbas ,  Shaun Devitt ,  Kenneth G. Schalhoub ,  Anthony Bitong ,  Mads Schjoth Due ,  Malak Guirguis ,  Rami Saifan

IPC: A61L2/20 ,  A61L2/26

Abstract: A method of externally sterilizing a drug delivery device utilizing Nitrogen Dioxide (NO2) is provided, including placing the drug delivery device in a sterilization chamber, introducing into the chamber a dose of NO2 having a concentration of between about 2 and 20 milligrams per Liter by applying a vacuum level of between about 10 and 600 Torr and holding the vacuum level for a dwell time of between about 2 and 20 minutes, repeating the step of introducing into the chamber a dose of NO2 for a number of pulses between about 1 and 24, purging the sterilization chamber of at least substantially all of the NO2, and aerating the sterilization chamber.

公开(公告)号：US12059555B2

公开(公告)日：2024-08-13

申请号：US17009868

申请日：2020-09-02

Applicant: AMGEN INC.

Inventor： Wael Mismar ,  Jessica Hai Liu ,  Dylan Bourelle ,  Chia-Jung Wu ,  Shaun Devitt ,  Kenneth G. Schalhoub ,  Tej Desai ,  Mads Schjoth Due ,  Anthony Bitong ,  Arin Keshishian ,  Chelsea Balli-Cruz ,  Pierre Burquel ,  Ryan Oba ,  Malak Guirguis

IPC: A61M5/31 ,  A61M5/00 ,  A61K38/17 ,  A61K39/395 ,  A61M5/315

CPC classification number: A61M5/3137 ,  A61M5/002 ,  A61K38/179 ,  A61K39/395 ,  A61M5/001 ,  A61M2005/3139 ,  A61M5/31505

Abstract: An injection device is provided, including a syringe having a barrel and a flange and a backstop configured to be coupled with the syringe adjacent to the flange. The backstop includes an inner surface generally extending around at least a portion of the syringe, wherein the inner surface includes at least one protrusion extending away from the inner surface and configured to engage the flange and/or the barrel to permit or promote airflow through a space between the inner surface and the syringe.

公开(公告)号：US20240366877A1

公开(公告)日：2024-11-07

申请号：US18674549

申请日：2024-05-24

Applicant: AMGEN INC.

Inventor： Wael Mismar ,  Jessica Hai Liu ,  Dylan Bourelle ,  Chia-Jung Wu ,  Shaun Devitt ,  Kenneth G. Schalhoub ,  Tej Desai ,  Mads Schjoth Due ,  Anthony Bitong ,  Arin Keshishian ,  Chelsea Balli-Cruz ,  Pierre Burquel ,  Ryan Oba ,  Malak Guirguis

IPC: A61M5/31 ,  A61K38/17 ,  A61K39/395 ,  A61M5/00 ,  A61M5/315

Abstract: An injection device is provided, including a syringe having a barrel and a flange and a backstop configured to be coupled with the syringe adjacent to the flange. The backstop includes an inner surface generally extending around at least a portion of the syringe, wherein the inner surface includes at least one protrusion extending away from the inner surface and configured to engage the flange and/or the barrel to permit or promote airflow through a space between the inner surface and the syringe.

公开(公告)号：US20210261297A1

公开(公告)日：2021-08-26

申请号：US17183515

申请日：2021-02-24

Applicant: AMGEN, INC.

Inventor： Anthony Bitong ,  Jessica Liu ,  Mads Schjoth Due ,  Wael Mismar ,  Greg Payne

IPC: B65D25/04 ,  A61L2/00

Abstract: A container and systems for use during an external sterilization process of a plurality of drug delivery devices are provided. The container may include an outer housing and at least one partition at least partially enclosed by the outer housing. The at least one partition may include a plurality of first dividers and a plurality of second dividers. The at least one partition may also be positioned an open configuration, wherein the plurality of first dividers and the plurality of second dividers cooperate with each other to define a plurality of chambers configured to receive at least one of the plurality of drug delivery devices. The at least one partition may also be positioned in a closed configuration wherein the plurality of chambers are substantially completely collapsed.

公开(公告)号：US12240652B2

公开(公告)日：2025-03-04

申请号：US17183515

申请日：2021-02-24

Applicant: AMGEN INC.

Inventor： Anthony Bitong ,  Jessica Liu ,  Mads Schjoth Due ,  Wael Mismar ,  Greg Payne

IPC: B65D25/04 ,  A61L2/00

Abstract: A container and systems for use during an external sterilization process of a plurality of drug delivery devices are provided. The container may include an outer housing and at least one partition at least partially enclosed by the outer housing. The at least one partition may include a plurality of first dividers and a plurality of second dividers. The at least one partition may also be positioned an open configuration, wherein the plurality of first dividers and the plurality of second dividers cooperate with each other to define a plurality of chambers configured to receive at least one of the plurality of drug delivery devices. The at least one partition may also be positioned in a closed configuration wherein the plurality of chambers are substantially completely collapsed.

公开(公告)号：US12233177B2

公开(公告)日：2025-02-25

申请号：US17022695

申请日：2020-09-16

Applicant: AMGEN INC.

Inventor： Wael Mismar ,  Jessica Hai Liu ,  Chia-Jung Wu ,  Shermeen A. Abbas ,  Shaun Devitt ,  Kenneth G. Schalhoub ,  Anthony Bitong ,  Mads Schjoth Due ,  Malak Guirguis ,  Rami Saifan

IPC: A61L2/20 ,  A61L2/26

Abstract: A method of externally sterilizing a drug delivery device utilizing Nitrogen Dioxide (NO2) is provided, including placing the drug delivery device in a sterilization chamber, introducing into the chamber a dose of NO2 having a concentration of between about 2 and 20 milligrams per Liter by applying a vacuum level of between about 10 and 600 Torr and holding the vacuum level for a dwell time of between about 2 and 20 minutes, repeating the step of introducing into the chamber a dose of NO2 for a number of pulses between about 1 and 24, purging the sterilization chamber of at least substantially all of the NO2, and aerating the sterilization chamber.

公开(公告)号：US20210060258A1

公开(公告)日：2021-03-04

申请号：US17009868

申请日：2020-09-02

Applicant: AMGEN INC.

Inventor： Wael Mismar ,  Jessica Hai Liu ,  Dylan Bourelle ,  Chia-Jung Wu ,  Shaun Devitt ,  Kenneth G. Schalhoub ,  Tej Desai ,  Mads Schjoth Due ,  Anthony Bitong ,  Arin Keshishian ,  Chelsea Balli-Cruz ,  Pierre Burquel ,  Ryan Oba ,  Malak Guirguis

IPC: A61M5/315 ,  A61M5/00 ,  A61M5/31 ,  A61K38/17 ,  A61K39/395

Abstract: An injection device is provided, including a syringe having a barrel and a flange and a backstop configured to be coupled with the syringe adjacent to the flange. The backstop includes an inner surface generally extending around at least a portion of the syringe, wherein the inner surface includes at least one protrusion extending away from the inner surface and configured to engage the flange and/or the barrel to permit or promote airflow through a space between the inner surface and the syringe.