公开(公告)号：US11866508B2

公开(公告)日：2024-01-09

申请号：US17142850

申请日：2021-01-06

Applicant: AMGEN INC.

Inventor： William Christian Fanslow, III ,  Carl Kozlosky ,  Jean Gudas

IPC: A61K39/00 ,  C07K16/30 ,  C07K16/46 ,  G01N33/68 ,  C07K16/28

CPC classification number: C07K16/30 ,  C07K16/28 ,  C07K16/2809 ,  C07K16/3046 ,  C07K16/468 ,  G01N33/6893 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92

Abstract: The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies and bispecific antibodies which specifically bind to mesothelin. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies, including methods of treating and preventing cancer or other hypoproliferative disorders and related disorders by administering such antigen binding proteins and antibodies to a subject in need of such treatment.

公开(公告)号：US20210380714A1

公开(公告)日：2021-12-09

申请号：US17142850

申请日：2021-01-06

Applicant: AMGEN INC.

Inventor： William Christian Fanslow, III ,  Carl Kozlosky ,  Jean Gudas

IPC: C07K16/30 ,  C07K16/46 ,  G01N33/68 ,  C07K16/28

Abstract: The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies and bispecific antibodies which specifically bind to mesothelin. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies, including methods of treating and preventing cancer or other hypoproliferative disorders and related disorders by administering such antigen binding proteins and antibodies to a subject in need of such treatment.