公开(公告)号：US20210380714A1

公开(公告)日：2021-12-09

申请号：US17142850

申请日：2021-01-06

Applicant: AMGEN INC.

Inventor： William Christian Fanslow, III ,  Carl Kozlosky ,  Jean Gudas

IPC: C07K16/30 ,  C07K16/46 ,  G01N33/68 ,  C07K16/28

Abstract: The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies and bispecific antibodies which specifically bind to mesothelin. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies, including methods of treating and preventing cancer or other hypoproliferative disorders and related disorders by administering such antigen binding proteins and antibodies to a subject in need of such treatment.

公开(公告)号：US10100121B2

公开(公告)日：2018-10-16

申请号：US15141463

申请日：2016-04-28

Applicant: AMGEN INC.

Inventor： William Christian Fanslow, III ,  Carl Kozlosky ,  Jean Marie Gudas

IPC: A61K39/395 ,  C07K16/30 ,  C07K16/46 ,  G01N33/68 ,  C07K16/28 ,  A61K39/00

Abstract: The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies and bispecific antibodies which specifically bind to mesothelin. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies, including methods of treating and preventing cancer or other hypoproliferative disorders and related disorders by administering such antigen binding proteins and antibodies to a subject in need of such treatment.

公开(公告)号：US10919975B2

公开(公告)日：2021-02-16

申请号：US16123827

申请日：2018-09-06

Applicant: AMGEN INC.

Inventor： William Christian Fanslow, III ,  Carl Kozlosky ,  Jean Marie Gudas

IPC: A61K39/00 ,  C07K16/30 ,  C07K16/46 ,  G01N33/68 ,  C07K16/28

Abstract: The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies and bispecific antibodies which specifically bind to mesothelin. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies, including methods of treating and preventing cancer or other hypoproliferative disorders and related disorders by administering such antigen binding proteins and antibodies to a subject in need of such treatment.

公开(公告)号：US20190055316A1

公开(公告)日：2019-02-21

申请号：US16123827

申请日：2018-09-06

Applicant: AMGEN INC.

Inventor： William Christian Fanslow, III ,  Carl Kozlosky ,  Jean Marie Gudas

IPC: C07K16/30

Abstract: The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies and bispecific antibodies which specifically bind to mesothelin. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies, including methods of treating and preventing cancer or other hypoproliferative disorders and related disorders by administering such antigen binding proteins and antibodies to a subject in need of such treatment.

公开(公告)号：US11866508B2

公开(公告)日：2024-01-09

申请号：US17142850

申请日：2021-01-06

Applicant: AMGEN INC.

Inventor： William Christian Fanslow, III ,  Carl Kozlosky ,  Jean Gudas

IPC: A61K39/00 ,  C07K16/30 ,  C07K16/46 ,  G01N33/68 ,  C07K16/28

CPC classification number: C07K16/30 ,  C07K16/28 ,  C07K16/2809 ,  C07K16/3046 ,  C07K16/468 ,  G01N33/6893 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92

Abstract: The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies and bispecific antibodies which specifically bind to mesothelin. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies, including methods of treating and preventing cancer or other hypoproliferative disorders and related disorders by administering such antigen binding proteins and antibodies to a subject in need of such treatment.

公开(公告)号：US20160340440A1

公开(公告)日：2016-11-24

申请号：US15141463

申请日：2016-04-28

Applicant: AMGEN INC.

Inventor： William Christian Fanslow, III ,  Carl Kozlosky ,  Jean Marie Gudas

IPC: C07K16/30 ,  C07K16/46 ,  C07K16/28

CPC classification number: C07K16/30 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2809 ,  C07K16/3046 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  G01N33/6893

Abstract: The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies and bispecific antibodies which specifically bind to mesothelin. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies, including methods of treating and preventing cancer or other hypoproliferative disorders and related disorders by administering such antigen binding proteins and antibodies to a subject in need of such treatment.

Abstract translation: 本公开提供了与抗原结合蛋白特别是特异性结合间皮素的抗体和双特异性抗体有关的组合物和方法。 本公开提供了编码这种抗原结合蛋白和抗体的核酸以及制备和使用这些抗体的方法，包括通过向需要这样的抗体的受试者施用此类抗原结合蛋白和抗体来治疗和预防癌症或其它低增殖性疾病和相关疾病的方法 治疗。

公开(公告)号：US20140004121A1

公开(公告)日：2014-01-02

申请号：US13926847

申请日：2013-06-25

Applicant: AMGEN INC.

Inventor： William Christian Fanslow, III ,  Carl Kozlosky ,  Jean Marie Gudas

IPC: C07K16/30 ,  G01N33/68 ,  C07K16/46

CPC classification number: C07K16/30 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2809 ,  C07K16/3046 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  G01N33/6893

Abstract: The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies and bispecific antibodies which specifically bind to mesothelin. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies, including methods of treating and preventing cancer or other hypoproliferative disorders and related disorders by administering such antigen binding proteins and antibodies to a subject in need of such treatment.

Abstract translation: 本公开提供了与抗原结合蛋白特别是特异性结合间皮素的抗体和双特异性抗体有关的组合物和方法。 本公开提供了编码这种抗原结合蛋白和抗体的核酸以及制备和使用这些抗体的方法，包括通过向需要这样的抗体的受试者施用此类抗原结合蛋白和抗体来治疗和预防癌症或其它低增殖性疾病和相关病症的方法 治疗。