公开(公告)号：US11918584B2

公开(公告)日：2024-03-05

申请号：US17870573

申请日：2022-07-21

Applicant: Amgen Inc.

Inventor： James Russell Lipford ,  Jude Robert Canon ,  Anne Y. Saiki ,  Karen Louise Rex

IPC: A61K31/519 ,  A61K31/498 ,  A61K31/506 ,  A61K31/555 ,  A61K45/06 ,  A61P35/00 ,  C07K16/28

CPC classification number: A61K31/519 ,  A61P35/00 ,  A61K31/555 ,  C07K16/2818

Abstract: The present invention provides combination therapy that includes an KRASG12C inhibitor, such as




or a pharmaceutically acceptable salt thereof, and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain an KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers.

公开(公告)号：US11439645B2

公开(公告)日：2022-09-13

申请号：US16687563

申请日：2019-11-18

Applicant: Amgen Inc.

Inventor： James Russell Lipford ,  Jude Robert Canon ,  Anne Y. Saiki ,  Karen Louise Rex

IPC: A61P35/00 ,  A61K45/06 ,  A61K31/519 ,  A61K31/506 ,  A61K31/555 ,  C07K16/28

Abstract: The present invention provides combination therapy that includes an KRASG12C inhibitor, such as or a pharmaceutically acceptable salt thereof, and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain an KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers.

公开(公告)号：US12280056B2

公开(公告)日：2025-04-22

申请号：US18545932

申请日：2023-12-19

Applicant: Amgen Inc.

Inventor： James Russell Lipford ,  Jude Robert Canon ,  Anne Y. Saiki ,  Karen Louise Rex

IPC: A61P35/00 ,  A61K31/506 ,  A61K31/519 ,  A61K31/555 ,  C07K16/28

Abstract: The present invention provides combination therapy that includes an KRASG12C inhibitor, such as or a pharmaceutically acceptable salt thereof, and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain an KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers.

公开(公告)号：US11426404B2

公开(公告)日：2022-08-30

申请号：US15930606

申请日：2020-05-13

Applicant: AMGEN INC.

Inventor： Haby Henary ,  James Russell Lipford ,  Victor J. Cee

IPC: A61K31/505 ,  A61P35/00 ,  A61K9/00 ,  A61K31/53 ,  A61K31/5355 ,  A61K39/00

Abstract: Provided herein are methods of administering a KRAS G12C inhibitor to a cancer subject.