公开(公告)号：US09914779B2

公开(公告)日：2018-03-13

申请号：US14360087

申请日：2012-11-21

Applicant: AMGEN INC.

Inventor： Dominique Christian Borie ,  Hailing Hsu ,  Wei-Jian Pan ,  William Rees ,  Barbara Anne Sullivan

IPC: A61K39/395 ,  C07K16/18 ,  C07K16/28 ,  G01N33/569 ,  A61K39/00

CPC classification number: C07K16/2842 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K16/2839 ,  C07K2317/90 ,  G01N33/56972 ,  G01N2333/70546 ,  G01N2800/065 ,  G01N2800/52

Abstract: There is provided a method of treating a subject afflicted with a condition that is associated with inappropriate trafficking of cells expressing alpha4beta7 to the gastrointestinal tract, comprising administering to the subject an alpha4beta7 heterodimer specific antibody in an amount and at an interval sufficient to ameliorate the condition.