公开(公告)号：US20210079051A1

公开(公告)日：2021-03-18

申请号：US17094968

申请日：2020-11-11

Applicant: AMGEN INC.

Inventor： Yumei XIONG ,  Yi ZHANG ,  Jackie Z. ZHENG ,  Agnes Eva HAMBURGER ,  Murielle M. VENIANT-ELLISON ,  Grant SHIMAMOTO ,  Xiaoshan MIN ,  Zhulun WANG ,  Jie TANG ,  Gunasekaran KANNAN ,  Marissa MOCK ,  Kenneth William WALKER

IPC: C07K14/475

Abstract: Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

公开(公告)号：US20200172614A1

公开(公告)日：2020-06-04

申请号：US16572271

申请日：2019-09-16

Applicant: AMGEN INC.

Inventor： Cen XU ,  Agnes Eva HAMBURGER

IPC: C07K16/28 ,  A61P25/06

Abstract: Antibodies and antigen-binding fragments thereof that bind to human PAC1 are provided. Nucleic acids encoding the antibodies and antigen-binding fragments thereof, vectors, and cells encoding the same are also provided. The antibodies and antigen-binding fragments thereof can inhibit binding of PAC1 to PACAP, and are useful in a number of PAC1 related disorders, including the treatment and/or prevention of headache disorders, including migraine and cluster headache.

公开(公告)号：US20210017261A1

公开(公告)日：2021-01-21

申请号：US16919032

申请日：2020-07-01

Applicant: AMGEN INC.

Inventor： Neeraj Jagdish AGRAWAL ,  Irwin CHEN ,  Su CHONG ,  Bryna FUCHSLOCHER ,  Kevin GRAHAM ,  Agnes Eva HAMBURGER ,  Mark Leo MICHAELS ,  Christopher MOHR ,  Derek E. PIPER ,  Kenneth William WALKER ,  Zhulun WANG ,  Cen XU

IPC: C07K16/18 ,  C07K16/28 ,  A61P25/06 ,  A61K38/22

Abstract: The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.

公开(公告)号：US20160168213A1

公开(公告)日：2016-06-16

申请号：US14908459

申请日：2014-07-31

Applicant: AMGEN INC.

Inventor： Yumei XIONG ,  Yi ZHANG ,  Jackie Z. SHENG ,  Agnes Eva HAMBURGER ,  Murielle VENIANT-ELLISON ,  Grant SHIMAMOTO ,  Xiaoshan MIN ,  Zhulun WANG ,  Jie TANG ,  Gunasekaran KANNAN ,  Marissa MOCK ,  Kenneth WALKER

IPC: C07K14/475

CPC classification number: C07K14/475 ,  C07K2319/30

Abstract: Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

Abstract translation: 提供了包含GDF15的构建体及其突变体。 在各种实施方案中，包含GDF15及其突变体的构建体可用于治疗或改善代谢紊乱。 在各种实施方案中，代谢疾病或病症是2型糖尿病，肥胖症，血脂异常，升高的葡萄糖水平，升高的胰岛素水平和糖尿病性肾病。

公开(公告)号：US20160039939A1

公开(公告)日：2016-02-11

申请号：US14775995

申请日：2014-03-14

Applicant: AMGEN INC.

Inventor： Cen XU ,  Agnes Eva HAMBURGER

IPC: C07K16/28

CPC classification number: C07K16/28 ,  C07K16/2869 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antibodies and antigen-binding fragments thereof that bind to human PAC1 are provided. Nucleic acids encoding the antibodies and antigen-binding fragments thereof, vectors, and cells encoding the same are also provided. The antibodies and antigen-binding fragments thereof can inhibit binding of PAC1 to PACAP, and are useful in a number of PAC1 related disorders, including the treatment and/or prevention of headache disorders, including migraine and cluster headache.

Abstract translation: 提供了结合人PAC1的抗体及其抗原结合片段。 还提供了编码抗体及其抗原结合片段，载体和编码其的细胞的核酸。 抗体及其抗原结合片段可以抑制PAC1与PACAP的结合，并且可用于许多PAC1相关病症，包括治疗和/或预防头痛障碍，包括偏头痛和丛集性头痛。

公开(公告)号：US20190315822A1

公开(公告)日：2019-10-17

申请号：US16416050

申请日：2019-05-17

Applicant: Amgen Inc.

Inventor： Yumei XIONG ,  Yi ZHANG ,  Jackie Z. SHENG ,  Agnes Eva HAMBURGER ,  Murielle M. VENIANT-ELLISON ,  Grant SHIMAMOTO ,  Xiaoshan MIN ,  Zhulun WANG ,  Jie TANG ,  Gunasekaran KANNAN ,  Kenneth W. WALKER ,  Bryan LEMON

IPC: C07K14/475 ,  A61K38/00 ,  C07K14/51 ,  A61K39/00 ,  A61K38/17 ,  A61K38/18 ,  C07K14/495 ,  A61K38/16

Abstract: GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

公开(公告)号：US20180094055A1

公开(公告)日：2018-04-05

申请号：US15787635

申请日：2017-10-18

Applicant: AMGEN INC.

Inventor： Cen XU ,  Agnes Eva HAMBURGER

IPC: C07K16/28

CPC classification number: C07K16/28 ,  C07K16/2869 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antibodies and antigen-binding fragments thereof that bind to human PAC1 are provided. Nucleic acids encoding the antibodies and antigen-binding fragments thereof, vectors, and cells encoding the same are also provided. The antibodies and antigen-binding fragments thereof can inhibit binding of PAC1 to PACAP, and are useful in a number of PAC1 related disorders, including the treatment and/or prevention of headache disorders, including migraine.

公开(公告)号：US20170291929A1

公开(公告)日：2017-10-12

申请号：US15625891

申请日：2017-06-16

Applicant: Amgen Inc.

Inventor： Yumei XIONG ,  Yi ZHANG ,  Jackie Z. SHENG ,  Agnes Eva HAMBURGER ,  Murielle M. VENIANT-ELLISON ,  Grant SHIMAMOTO ,  Xiaoshan MIN ,  Zhulun WANG ,  Jie TANG ,  Gunasekaran KANNAN ,  Kenneth W. WALKER ,  Bryan LEMON

IPC: C07K14/475 ,  A61K39/00

CPC classification number: C07K14/475 ,  A61K38/00 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61K39/0005 ,  A61K2039/6056 ,  C07K14/495 ,  C07K14/51 ,  C07K2319/30

Abstract: GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

公开(公告)号：US20160251432A1

公开(公告)日：2016-09-01

申请号：US15158178

申请日：2016-05-18

Applicant: AMGEN INC.

Inventor： Cen XU ,  Agnes Eva HAMBURGER

IPC: C07K16/28

CPC classification number: C07K16/28 ,  C07K16/2869 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antibodies and antigen-binding fragments thereof that bind to human PAC1 are provided. Nucleic acids encoding the antibodies and antigen-binding fragments thereof, vectors, and cells encoding the same are also provided. The antibodies and antigen-binding fragments thereof can inhibit binding of PAC1 to PACAP, and are useful in a number of PAC1 related disorders, including the treatment and/or prevention of headache disorders, including migraine.

公开(公告)号：US20240368236A1

公开(公告)日：2024-11-07

申请号：US18639202

申请日：2024-04-18

Applicant: Amgen Inc.

Inventor： Yumei XIONG ,  Yi ZHANG ,  Jackie Z. SHENG ,  Agnes Eva HAMBURGER ,  Murielle M. VENIANT-ELLISON ,  Grant SHIMAMOTO ,  Xiaoshan MIN ,  Zhulun WANG ,  Jie TANG ,  Gunasekaran KANNAN ,  Marissa MOCK ,  Kenneth William WALKER

IPC: C07K14/475

Abstract: Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.