公开(公告)号：US10570416B2

公开(公告)日：2020-02-25

申请号：US15234949

申请日：2016-08-11

申请人： ALPHAVAX, INC.

发明人： Jon O. Rayner ,  Jonathan F. Smith ,  Bolyn Hubby ,  Elizabeth A. Reap

IPC分类号： C12N15/86 ,  A61K39/21 ,  C12N7/00 ,  A61K39/12 ,  C07K14/005 ,  A61K39/00 ,  A61K48/00

摘要： The present disclosure provides TC-83 VEE-derived replicons, alphaviral replicon particles and immunogenic compositions containing TC-83 alphaviral replicon particles which direct the expression of at least one antigen when introduced into a suitable host cell. The TC-83 VEE-derived ARPs described herein are improved in that they are subject to a lower vector-specific immune response than prior art ARPs.

公开(公告)号：US09441247B2

公开(公告)日：2016-09-13

申请号：US14792247

申请日：2015-07-06

申请人： AlphaVax, Inc.

发明人： Jon O. Rayner ,  Jonathan F. Smith ,  Bolyn Hubby ,  Elizabeth A. Reap

IPC分类号： C12N15/86 ,  A61K39/21 ,  C07K14/005 ,  C12N7/00 ,  A61K39/12 ,  A61K48/00 ,  A61K39/00

CPC分类号： C12N15/86 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/21 ,  A61K48/00 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/575 ,  C07K14/005 ,  C12N7/00 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2770/36123 ,  C12N2770/36134 ,  C12N2770/36143 ,  C12N2770/36152 ,  C12N2770/36162 ,  C12N2840/203

摘要： The present disclosure provides TC-83 VEE-derived replicons, alphaviral replicon particles and immunogenic compositions containing TC-83 alphaviral replicon particles which direct the expression of at least one antigen when introduced into a suitable host cell. The TC-83 VEE-derived ARPs described herein are improved in that they are subject to a lower vector-specific immune response than prior art ARPs.

公开(公告)号：US09079943B2

公开(公告)日：2015-07-14

申请号：US14229736

申请日：2014-03-28

申请人： AlphaVax, Inc.

发明人： Jon O. Rayner ,  Jonathan F. Smith ,  Bolyn Hubby ,  Elizabeth A. Reap

IPC分类号： C12N15/86 ,  C07K14/005 ,  A61K39/21 ,  C12N7/00 ,  A61K39/193 ,  A61K39/295 ,  A61K48/00 ,  A61K39/00

CPC分类号： C12N15/86 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/21 ,  A61K48/00 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/575 ,  C07K14/005 ,  C12N7/00 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2770/36123 ,  C12N2770/36134 ,  C12N2770/36143 ,  C12N2770/36152 ,  C12N2770/36162 ,  C12N2840/203

摘要： The present disclosure provides TC-83 VEE-derived replicons, alphaviral replicon particles and immunogenic compositions containing TC-83 alphaviral replicon particles which direct the expression of at least one antigen when introduced into a suitable host cell. The TC-83 VEE-derived ARPs described herein are improved in that they are subject to a lower vector-specific immune response than prior art ARPs.

摘要翻译： 本公开提供了TC-83VEE衍生的复制子，甲病毒复制子颗粒和含有TC-83甲病毒复制子颗粒的免疫原性组合物，其在引入合适的宿主细胞时引导至少一种抗原的表达。 本文描述的TC-83VEE衍生的ARP被改进，因为它们比现有技术的ARP受到较低的载体特异性免疫应答。