公开(公告)号：US11466056B2

公开(公告)日：2022-10-11

申请号：US16307719

申请日：2017-06-08

申请人： ALMA MATER STUDIORUM UNIVERSITA DI BOLOGNA

发明人： Valerio Leoni ,  Maria Gabriella Campadelli

IPC分类号： C07K14/005 ,  A61P35/00 ,  A61K35/763 ,  A61K45/06 ,  C07K14/39 ,  C07K16/32 ,  C12N5/09 ,  C12N7/00

摘要： The present invention is directed to a recombinant herpesvirus comprising a heterologous peptide and optionally polypeptide ligand capable of binding to (a) target molecule(s) and fused to or inserted into glycoprotein D. The recombinant herpesvirus may additionally comprise modifications for detargeting the virus from the natural receptors of gD. This allows the herpesvirus to efficiently target a cell for therapeutic purposes and a cell for virus production. The present invention further comprises a pharmaceutical composition comprising the herpesvirus, the herpesvirus for use in the treatment of a tumor, infection, degenerative disorder or senescence-associated disease, a nucleic acid and a vector coding for the gD, a polypeptide comprising the gD, and a cell comprising the herpesvirus, nucleic acid, vector or polypeptide. Moreover, a method for infecting a cell with the herpesvirus or for producing the herpesvirus is disclosed.