公开(公告)号：US20180201604A1

公开(公告)日：2018-07-19

申请号：US15568449

申请日：2016-04-20

申请人： ALLGENESIS BIOTHERAPEUTICS, INC.

发明人： Madhu CHERUKURY ,  Hsiao-Wen LIN ,  Shu Chieh YU ,  Riping PHANG ,  Yesudoss Christu RAJAN ,  Diane Dan-Shya TANG-LIU ,  Andrew D. WHITE ,  Thomas MALONE ,  Richard BERESIS

IPC分类号： C07D403/04 ,  C07D409/04 ,  C07D409/14 ,  C07D405/04 ,  C07D405/14 ,  C07D401/12 ,  C07D401/04 ,  C07D401/06 ,  C07D417/04 ,  C07D417/08 ,  C07D417/14 ,  C07D413/04 ,  C07D413/08 ,  C07D403/10 ,  C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D491/048 ,  C07D495/04 ,  C07D498/04 ,  C07D239/22 ,  C07D513/10 ,  A61P25/28

CPC分类号： C07D403/04 ,  A61P25/28 ,  C07D239/22 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/10 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/08 ,  C07D417/04 ,  C07D417/08 ,  C07D417/14 ,  C07D471/04 ,  C07D471/14 ,  C07D491/048 ,  C07D495/04 ,  C07D498/04 ,  C07D513/10

摘要： The present invention relates to compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein X, Y, Z, Q, W, m, u, ring (A), R2, R3, R4, R5 and R6, are as defined in the specification and claims. The present invention provides a pharmaceutical composition containing the compounds of Formula (I) and a therapeutic method of treating and/or preventing Downs syndrome, β-amyloid angiopathy, disorders associated with cognitive impairment, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegenerative diseases, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, Alzheimer's disease and/or Down syndrome, age-related macular degeneration (AMD), glaucoma, olfactory function impairment, traumatic brain injury, progressive muscle diseases, Type II diabetes mellitus and cardiovascular diseases (stroke).