公开(公告)号：US11337929B2

公开(公告)日：2022-05-24

申请号：US16484870

申请日：2018-02-08

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Moon Suk Kim ,  Ji Yeon Heo

IPC: A61K31/496 ,  A61K9/50 ,  A61K9/00 ,  A61K45/06

Abstract: A drug delivery formulation for treating a mental illness or a central nervous system disorder is disclosed. The drug delivery formulation includes a microcapsule containing a biodegradable polymer and a drug and a crosslinked hydrogel and a method for preparing the same. The drug delivery formulation can slowly release a drug at a constant rate without a burst of drug release in the early stage of drug administration to maintain a constant blood drug level over a long period of time and thus enjoys the advantage of preventing excessive initial release of drug, thereby obtaining a desirable sustained release profile by single administration without necessity for multiple administrations divided at regular time intervals.