公开(公告)号：US20230374558A1

公开(公告)日：2023-11-23

申请号：US18350982

申请日：2023-07-12

Applicant: AJINOMOTO CO., INC. ,  EVOLVA SA

Inventor： Howard RIEZMAN ,  Sabina de Andrade Pereira TAVARES ,  Markus SCHWAB ,  Vsevolod Aleksandrovich SEREBRIANYI ,  Olga Aleksandrovna SOFYANOVICH ,  Anna Mikhailovna OZEROVA ,  Naoki IWANAGA

IPC: C12P13/02 ,  C12P19/44 ,  C12N9/16 ,  C12N15/81

CPC classification number: C12P13/02 ,  C12P19/44 ,  C12N9/16 ,  C12Y301/03004 ,  C12N15/81 ,  C12N2800/102

Abstract: A method for producing an objective substance such as phytosphingosine (PHS) and phytoceramide (PHC) using yeast is provided. The objective substance is produced by cultivating yeast having an ability to produce the objective substance and modified so that the expression and/or activity of a protein(s) encoded by NEM1 and/or SPO7 gene(s) is reduced in a culture medium.