公开(公告)号：US20240350468A1

公开(公告)日：2024-10-24

申请号：US18751439

申请日：2024-06-24

申请人： AICURIS GMBH & CO. KG

发明人： Yogeshwar BACHHAV ,  Wilfried SCHWAB ,  Alexander BIRKMANN ,  Susanne BONSMANN ,  Thomas GOLDNER

IPC分类号： A61K31/4439 ,  A61K9/00 ,  A61K45/06 ,  C07D417/12

CPC分类号： A61K31/4439 ,  A61K9/0014 ,  A61K45/06 ,  C07D417/12

摘要： The present invention relates to the field of anti-viral active agents, particularly to salts, more particularly to a maleate salt of the free base of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide, to pharmaceutical formulations thereof as well as to methods for the production of these salts. The present invention also relates to the use of theses salts and of respective pharmaceutical formulations thereof in methods of treatment and/or prevention of human herpes simplex virus infections, particularly infections caused by HSV-1 and HSV-2.

公开(公告)号：US20220152009A1

公开(公告)日：2022-05-19

申请号：US17585145

申请日：2022-01-26

申请人： AICURIS GMBH & CO. KG

发明人： Yogeshwar BACHHAV ,  Wilfried SCHWAB ,  Alexander BIRKMANN ,  Susanne BONSMANN ,  Thomas GOLDNER

IPC分类号： A61K31/4439 ,  A61K9/00 ,  A61K45/06 ,  C07D417/12

摘要： The present invention relates to the field of anti-viral active agents, particularly to salts, more particularly to a maleate salt of the free base of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide, to pharmaceutical formulations thereof as well as to methods for the production of these salts. The present invention also relates to the use of theses salts and of respective pharmaceutical formulations thereof in methods of treatment and/or prevention of human herpes simplex virus infections, particularly infections caused by HSV-1 and HSV-2.