公开(公告)号：US20240350468A1

公开(公告)日：2024-10-24

申请号：US18751439

申请日：2024-06-24

Applicant: AICURIS GMBH & CO. KG

Inventor： Yogeshwar BACHHAV ,  Wilfried SCHWAB ,  Alexander BIRKMANN ,  Susanne BONSMANN ,  Thomas GOLDNER

IPC: A61K31/4439 ,  A61K9/00 ,  A61K45/06 ,  C07D417/12

CPC classification number: A61K31/4439 ,  A61K9/0014 ,  A61K45/06 ,  C07D417/12

Abstract: The present invention relates to the field of anti-viral active agents, particularly to salts, more particularly to a maleate salt of the free base of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide, to pharmaceutical formulations thereof as well as to methods for the production of these salts. The present invention also relates to the use of theses salts and of respective pharmaceutical formulations thereof in methods of treatment and/or prevention of human herpes simplex virus infections, particularly infections caused by HSV-1 and HSV-2.

公开(公告)号：US20220306647A1

公开(公告)日：2022-09-29

申请号：US17607605

申请日：2020-04-29

Applicant: AICURIS GMBH & CO. KG

Inventor： Susanne BONSMANN ,  Alastair DONALD ,  Andreas URBAN ,  Burkhard KLENKE ,  Jasper SPRINGER

IPC: C07D498/04 ,  C07D487/04 ,  C07D471/04 ,  C07D471/14

Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

公开(公告)号：US20220009931A1

公开(公告)日：2022-01-13

申请号：US17290541

申请日：2019-11-01

Applicant: AICURIS GMBH & CO. KG

Inventor： Alastair DONALD ,  Andreas URBAN ,  Susanne BONSMANN

IPC: C07D487/04

Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

公开(公告)号：US20220152009A1

公开(公告)日：2022-05-19

申请号：US17585145

申请日：2022-01-26

Applicant: AICURIS GMBH & CO. KG

Inventor： Yogeshwar BACHHAV ,  Wilfried SCHWAB ,  Alexander BIRKMANN ,  Susanne BONSMANN ,  Thomas GOLDNER

IPC: A61K31/4439 ,  A61K9/00 ,  A61K45/06 ,  C07D417/12

Abstract: The present invention relates to the field of anti-viral active agents, particularly to salts, more particularly to a maleate salt of the free base of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide, to pharmaceutical formulations thereof as well as to methods for the production of these salts. The present invention also relates to the use of theses salts and of respective pharmaceutical formulations thereof in methods of treatment and/or prevention of human herpes simplex virus infections, particularly infections caused by HSV-1 and HSV-2.

公开(公告)号：US20220009922A1

公开(公告)日：2022-01-13

申请号：US17290354

申请日：2019-11-01

Applicant: AiCuris GmbH & Co. KG

Inventor： Alastair DONALD ,  Andreas URBAN ,  Susanne BONSMANN

IPC: C07D471/04 ,  A61P31/20

Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

公开(公告)号：US20220227737A1

公开(公告)日：2022-07-21

申请号：US17607430

申请日：2020-04-29

Applicant: AiCuris GmbH & Co. KG

Inventor： Susanne BONSMANN ,  Alastair DONALD ,  Andreas URBAN ,  Thomas GOLDNER ,  Miquel Angel PERICAS BRONDO ,  Esther Alza BARRIOS ,  Elena DETTA ,  Justine RAYMOND

IPC: C07D403/06 ,  C07D405/12 ,  C07D403/12 ,  A61P31/20

Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

公开(公告)号：US20220081444A1

公开(公告)日：2022-03-17

申请号：US17290347

申请日：2019-11-01

Applicant: AiCuris GmbH & Co. KG

Inventor： Alastair DONALD ,  Andreas URBAN ,  Susanne BONSMANN ,  Jasper SPRINGER ,  Anita WEGERT

IPC: C07D487/04 ,  A61P31/20 ,  C07D519/00

Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

公开(公告)号：US20210179608A1

公开(公告)日：2021-06-17

申请号：US16760929

申请日：2018-11-02

Applicant: AiCuris GmbH & Co. KG

Inventor： Alastair DONALD ,  Andreas URBAN ,  Susanne BONSMANN ,  Anita WEGERT ,  Jasper SPRINGER

IPC: C07D471/04

Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

公开(公告)号：US20220363686A1

公开(公告)日：2022-11-17

申请号：US17290357

申请日：2019-11-01

Applicant: AiCuris GmbH & Co. KG

Inventor： Alastair DONALD ,  Andreas URBAN ,  Susanne BONSMANN ,  Jasper SPRINGER ,  Anita WEGERT

IPC: C07D487/04 ,  A61P31/20

Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

公开(公告)号：US20220009945A1

公开(公告)日：2022-01-13

申请号：US17290504

申请日：2019-11-01

Applicant: AICURIS GMBH & CO. KG

Inventor： Alastair DONALD ,  Andreas URBAN ,  Susanne BONSMANN

IPC: C07D513/04

Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.