公开(公告)号：US12054543B2

公开(公告)日：2024-08-06

申请号：US17262351

申请日：2019-07-24

Applicant: ACCURUS BIOSCIENCES, INC.

Inventor： Haishan Lin ,  Richard Zhang

IPC: C07K16/28 ,  A61K47/68 ,  C07K14/705 ,  C07K14/725 ,  G01N33/68

CPC classification number: C07K16/28 ,  A61K47/6849 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70578 ,  G01N33/6854 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/30 ,  C07K2319/33

Abstract: Provided herein are novel anti-CLDN 18.2 antibodies and chimeric antigen receptors (CAR), cells or compositions comprising the same, vector or plasmid encoding anti-CLDN 18.2 CAR, anti-CLDN 18.2 antibody-drug conjugates (ADCs), bispecific antibodies containing anti-CLDN 18.2 antibodies, and methods for producing the same, or using the same for detecting or treating ovarian cancer or prostate cancer. Also provided herein are anti-CLDN 18.2 antibodies, compositions comprising the same, nucleic acid sequence encoding the same, and a kit for detecting CLDN 18.2.

公开(公告)号：US20240336680A1

公开(公告)日：2024-10-10

申请号：US18753205

申请日：2024-06-25

Applicant: ACCURUS BIOSCIENCES, INC.

Inventor： Haishan Lin ,  Richard Zhang

IPC: C07K16/28 ,  A61K47/68 ,  C07K14/705 ,  C07K14/725 ,  G01N33/68

CPC classification number: C07K16/28 ,  A61K47/6849 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70578 ,  G01N33/6854 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/30 ,  C07K2319/33

Abstract: Provided herein are novel anti-CLDN 18.2 antibodies and chimeric antigen receptors (CAR), cells or compositions comprising the same, vector or plasmid encoding anti-CLDN 18.2 CAR, anti-CLDN18.2 antibody-drug conjugates (ADCs), bispecific antibodies containing anti-CLDN 18.2 antibody, and methods for producing the same, or using the same for detecting or treating ovarian cancer or prostate cancer. Also provided herein are anti-CLDN 18.2 antibody, compositions comprising the same, nucleic acid sequence encoding the same, and a kit for detecting CLDN 18.2.

公开(公告)号：US20210214433A1

公开(公告)日：2021-07-15

申请号：US17262351

申请日：2019-07-24

Applicant: ACCURUS BIOSCIENCES, INC.

Inventor： Haishan Lin ,  Richard Zhang

IPC: C07K16/28 ,  C07K14/705 ,  C07K14/725 ,  G01N33/68 ,  A61K47/68

Abstract: Provided herein are novel anti-CLDN 18.2 antibodies and chimeric antigen receptors (CAR), cells or compositions comprising the same, vector or plasmid encoding anti-CLDN 18.2 CAR, anti-CLDN 18.2 antibody-drug conjugates (ADCs), bispecific antibodies containing anti-CLDN 18.2 antibody, and methods for producing the same, or using the same for detecting or treating ovarian cancer or prostate cancer. Also provided herein are anti-CLDN 18.2 antibody, compositions comprising the same, nucleic acid sequence encoding the same, and a kit for detecting CLDN 18.2.