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公开(公告)号：US20230145342A1
公开(公告)日：2023-05-11
申请号：US17917338
申请日：2021-04-07
发明人： Christopher JONKERGOUW , Ekaterina OSMEKHINA , Markus LINDER , Katarzyna LESKINEN , Päivi SAAVALAINEN
IPC分类号： A61K31/05 , A61K31/7036 , A61K31/546 , A61K38/12 , A61K31/407 , A61K31/5383 , A61K31/427 , A61P31/04
CPC分类号： A61K31/05 , A61K31/7036 , A61K31/546 , A61K38/12 , A61K31/407 , A61K31/5383 , A61K31/427 , A61P31/04
摘要： This invention relates to use of a macrocyclic cavity-containing compound sensitizing a microbe towards an antimicrobial agent. The invention also relates to use of a macrocyclic cavity-containing compound in reducing the amount of an antimicrobial agent needed to prevent or inhibit the growth of a microbe in a subject. Further, the invention relates to use of a macrocyclic cavity-containing compound in reducing the build-up of resistance of a microbe towards an anti-microbial agent. The invention also relates to a macrocyclic cavity-containing compound and an antimicrobial agent for use in inhibiting/treating/preventing a microbial infection in a subject having a microbial infection or being at risk of a microbial infection.
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公开(公告)号：US20230226099A1
公开(公告)日：2023-07-20
申请号：US17917346
申请日：2021-04-07
发明人： Christopher JONKERGOUW , Nurcin UGUR , Markus LINDER , Janne RAULA , Esko KAUPPINEN , Ekaterina OSMEKHINA
IPC分类号： A61K31/724 , A61K31/407 , A61K31/7036 , A61K31/5383 , A61K9/00 , A61K9/16 , A61P31/04
CPC分类号： A61K31/724 , A61K31/407 , A61K31/7036 , A61K31/5383 , A61K9/0075 , A61K9/0078 , A61K9/1623 , A61P31/04
摘要： This invention relates to inhalable formulation comprising a macrocyclic, cavity-containing compound as a biologically active ingredient. The present invention relates also to an inhalable formulation comprising a macrocyclic, cavity-containing compound as a biologically active ingredient for use in a method of treating an infection in a subject. In addition, the present invention relates to a method of treating an infection in a subject by administering an inhalable formulation comprising a macrocyclic, cavity-containing compound as a biologically active ingredient to the subject. The inhalable formulation comprising a macrocyclic, cavity-containing compound as a biologically active ingredient is suitable for the treatment of pulmonary or systemic infections caused by Gram-positive or Gram-negative bacteria.
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公开(公告)号：US20220008364A1
公开(公告)日：2022-01-13
申请号：US17283471
申请日：2019-10-08
IPC分类号： A61K31/14 , A61P31/04 , A61K31/4188 , A61K31/357
摘要： This invention relates to macrocyclic cavity containing compounds and uses thereof in inhibiting a microbial signalling molecule or in reducing the amount of a microbial signalling molecule in a subject. The invention also relates to methods for inhibiting a microbial signalling molecule or for reducing the amount of a microbial signalling molecule in a subject by contacting a macrocyclic cavity-containing compound with said subject.
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