专利检索 ap:("858 Therapeutics, Inc.") AND inv:"Jeffrey A. Stafford" 第 1 页

1.

发明授权
Substituted imidazo[1,2-a]quinazolines and imidazo [1,2-a]pyrido[4,3-e]pyrimidines as inhibitors of PARG 有权

公开(公告)号：US11939335B2

公开(公告)日：2024-03-26

申请号：US18199900

申请日：2023-05-19

申请人： 858 Therapeutics, Inc.

发明人： James M. Veal , Jeffrey A. Stafford , Donald S. Karanewsky , Shyama Herath

IPC分类号： A61K31/519 , C07D487/04 , C07D487/14 , C07D491/147 , C07D491/20 , C07D519/00

CPC分类号： C07D487/04 , C07D491/147 , C07D491/20 , C07D519/00 , C07B2200/05

摘要： Provided herein are inhibitors of PARG, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the PARG inhibitory compounds for the treatment of disease. Said inhibitors of PARG have the structure provided in Formula (I):

as represented, for example, by Example 1: