公开(公告)号：US20240352018A1

公开(公告)日：2024-10-24

申请号：US18441757

申请日：2024-02-14

Applicant: 858 Therapeutics, Inc.

Inventor： James M. VEAL ,  Jeffrey A. STAFFORD ,  Donald S. KARANEWSKY ,  Shyama HERATH

IPC: C07D487/04 ,  C07D491/147 ,  C07D491/20 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D491/147 ,  C07D491/20 ,  C07D519/00 ,  C07B2200/05

Abstract: Provided herein are inhibitors of PARG, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the PARG inhibitory compounds for the treatment of disease.

公开(公告)号：US20250059207A1

公开(公告)日：2025-02-20

申请号：US18718735

申请日：2022-12-27

Applicant: 858 Therapeutics, Inc.

Inventor： Zacharia S. CHERUVALLATH ,  James M. VEAL ,  Jeffrey A. STAFFORD ,  Christopher MCBRIDE

IPC: C07D519/00 ,  A61K31/4375 ,  A61K31/438 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4995 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/5386 ,  A61P35/02 ,  C07D471/04

Abstract: The present disclosure relates to 6,6-fused heterocyclic compounds and related compounds and their use in treating a disease or condition responsive to modulation or inhibition of METTL3.

公开(公告)号：US11939335B2

公开(公告)日：2024-03-26

申请号：US18199900

申请日：2023-05-19

Applicant: 858 Therapeutics, Inc.

Inventor： James M. Veal ,  Jeffrey A. Stafford ,  Donald S. Karanewsky ,  Shyama Herath

IPC: A61K31/519 ,  C07D487/04 ,  C07D487/14 ,  C07D491/147 ,  C07D491/20 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D491/147 ,  C07D491/20 ,  C07D519/00 ,  C07B2200/05

Abstract: Provided herein are inhibitors of PARG, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the PARG inhibitory compounds for the treatment of disease. Said inhibitors of PARG have the structure provided in Formula (I):




as represented, for example, by Example 1:

公开(公告)号：US20230374022A1

公开(公告)日：2023-11-23

申请号：US18199900

申请日：2023-05-19

Applicant: 858 Therapeutics, Inc.

Inventor： James M. VEAL ,  Jeffrey A. STAFFORD ,  Donald S. KARANEWSKY ,  Shyama HERATH

IPC: C07D487/04 ,  C07D491/147 ,  C07D491/20 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D491/147 ,  C07D491/20 ,  C07D519/00 ,  C07B2200/05

Abstract: Provided herein are inhibitors of PARG, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the PARG inhibitory compounds for the treatment of disease.